Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-H2O systems
| Autor: | P. S. Parvathanathan, C.L. Khetrapal, S. Raghotama, N. Suryaprakash, K. Usha Deniz, Geeta Datta, K. V. Ramanathan |
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| Rok vydání: | 1990 |
| Předmět: |
Diphenyl sulfone
Vesicle Doping technology industry and agriculture Sophisticated Instruments Facility General Medicine General Biochemistry Genetics and Molecular Biology Sulfone chemistry.chemical_compound Nuclear magnetic resonance Differential scanning calorimetry chemistry heterocyclic compounds lipids (amino acids peptides and proteins) Phosphatidyl choline General Agricultural and Biological Sciences |
| Zdroj: | Journal of Biosciences. 15:117-123 |
| ISSN: | 0973-7138 0250-5991 |
| DOI: | 10.1007/bf02703871 |
| Popis: | The influence of the sulfone drugs, diamino diphenyl sulfone and diamino monophenyl sulfone on the phase transitions and dynamics of dipalmitoyl phosphatidyl choline-$H_2O/D_2O$ vesicles have been investigated using differential scanning calorimetry and nuclear magnetic resonance. Our results show that diamino diphenyl sulfone interacts quite strongly with the headgroups of dipalmitoyl phosphatidyl choline whereas the diamino monophenyl sulfone-dipalmitoyl phosphatidyl choline interaction is quite weak. This is attributed to the difference in the structure and hydrophobic character of the two drugs. |
| Databáze: | OpenAIRE |
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