Ceruoplasmin Is Increased in Cerebrospinal Fluid in Alzheimerʼs Disease but Not Parkinsonʼs Disease
| Autor: | Nunzio Pomara, P. A. LeWitt, G. A. Mashour, J. H. Finkelman, P. L. Juneau, D. A. Loeffler, C. M. Brickman, A. J. DeMaggio |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Parkinson's disease Systemic inflammation medicine.disease_cause Diagnosis Differential Central nervous system disease Cerebrospinal fluid Alzheimer Disease Internal medicine medicine Humans Aged Aged 80 and over chemistry.chemical_classification biology business.industry Transferrin Brain Ceruloplasmin Parkinson Disease Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Endocrinology chemistry biology.protein Dementia Female Geriatrics and Gerontology medicine.symptom Alzheimer's disease business Gerontology Oxidative stress |
| Zdroj: | Alzheimer Disease & Associated Disorders. 8:190-197 |
| ISSN: | 0893-0341 |
| DOI: | 10.1097/00002093-199408030-00005 |
| Popis: | Although the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) is unknown, altered brain antioxidative mechanisms have been found in both disorders. Ceruloplasmin (CP) and transferrin (TF) interact to limit concentrations of free ferrous iron (Fe2+), and thus play an important role in antioxidant defense in serum; both proteins are also produced in brain, where their significance as antioxidants is unknown. We quantified concentrations of CP and TF by immunoassay in AD (n = 17) and PD (n = 12) cerebrospinal fluid (CSF) to determine whether these proteins could serve as disease markers. CP was increased versus aged normal subjects (n = 11) in AD (p < 0.05) but not PD CSF, whereas TF concentrations did not differ between groups. CP levels have been reported to be elevated in some brain regions in AD, and increased CP in AD CSF may reflect this finding. Systemic inflammation and oxidative stress are major factors stimulating hepatic CP synthesis, and it remains to be determined whether increased CP concentrations in AD CSF and brain follow from similar mechanisms. |
| Databáze: | OpenAIRE |
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