A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle
| Autor: | Ulziiburen Chimedregze, Shun Ishibashi, Lkhagvasuren Munkhtulga, Ayumi Ogawa, Takaya Gotoh, Kazuhiro Nakayama, Tumenbayer Bayasgalan, Yasuo Kagawa, Fumiko Tazoe, Sadahiko Iwamoto, Yoshiko Yanagisawa, Kazuhiro Yamanaka |
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| Rok vydání: | 2009 |
| Předmět: |
Fatty Acid Desaturases
Linkage disequilibrium Genotype FADS1 Population Genome-wide association study Single-nucleotide polymorphism Locus (genetics) Biology Polymorphism Single Nucleotide Linkage Disequilibrium Delta-5 Fatty Acid Desaturase Asian People Genetics Ethnicity Humans Allele education Life Style Genetics (clinical) Genetic Association Studies Triglycerides education.field_of_study Haplotype Cholesterol HDL Cholesterol LDL Lipids Haplotypes lipids (amino acids peptides and proteins) Genome-Wide Association Study |
| Zdroj: | Human genetics. 127(6) |
| ISSN: | 1432-1203 |
| Popis: | Recent genome-wide association studies (GWASs) showed that single nucleotide polymorphisms (SNPs) in FADS1/FADS2 were associated with plasma lipid concentrations in populations with European ancestry. We investigated the associations between the SNPs in FADS1/FADS2 and plasma concentrations of triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in two Asian groups, i.e., Japanese and Mongolians. The genotype of rs174547 (T/C), found to be associated with triglyceride and HDL-C concentrations in the GWAS, was determined in 21,004 Japanese and 1,203 Mongolian individuals. Genotype-phenotype association was assessed by using multiple linear regression models, assuming an additive model of inheritance. The copy number of the rs174547 C allele was significantly associated with increased triglyceride levels (P = 1.5 x 10(-6)) and decreased HDL-C levels (P = 0.03) in the Japanese population. On the other hand, in the Mongolian population, the rs174547 C allele copy number was strongly associated with decreased LDL-C levels (P = 2.6 x 10(-6)), but was not associated with triglyceride and HDL-C levels. The linkage disequilibrium pattern and haplotype structures of SNPs around the FADS1/FADS2 locus showed no marked dissimilarity between Japanese and Mongolian individuals. The present data indicate that the FADS1/FADS2 locus can be added to the growing list of loci involved in polygenic dyslipidemia in Asians. Furthermore, the variable effects of FADS1/FADS2 on plasma lipid profiles in Asians may result from differences in the dietary intake of polyunsaturated fatty acids, which serve as substrates for enzymes encoded by FADS1/FADS2. |
| Databáze: | OpenAIRE |
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