Differential expression of miRNAs related to angiogenesis and adipogenesis in subcutaneous fat of obese and nonobese women

Autor:	Márcia Rodrigues Terres, Adriana Milani, Darwin Lizot Rech, Diego Olschowsky Borges, Nelson Guardiola Meihnardt, Vanessa Suñé Mattevi, Marina Gomes de Moraes Sassi, Aline S. Gasparotto, Mauricio Jacques Ramos, Pedro Bins Ely
Rok vydání:	2018
Předmět:	0301 basic medicine Adult medicine.medical_specialty Angiogenesis Subcutaneous Fat Adipose tissue Neovascularization Physiologic Inflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine microRNA Genetics Medicine Humans Obesity Molecular Biology Adipogenesis business.industry miR-27 Gene Expression Profiling General Medicine Vascular endothelial growth factor MicroRNAs 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Female medicine.symptom business Body mass index
Zdroj:	Molecular biology reports. 46(1)
ISSN:	1573-4978
Popis:	To disclose the mechanisms surrounding obesity, we selected microRNAs (miRNAs) that target genes involved in adipogenesis, angiogenesis, and inflammation and compared their expression levels in the subcutaneous adipose tissue of 40 obese and nonobese women. Mature miRNAs were extracted from subcutaneous adipose tissue samples that were collected during surgery and quantified by real-time polymerase chain reaction. miR-16 was overexpressed in the nonobese group (n-expression ratio = − 151.1; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c319024b513b39b628c25dc2582742 https://pubmed.ncbi.nlm.nih.gov/30565074 Zobrazit plný text záznamu Full text from SpringerLink