Antithrombogenicity of Polyacrylonitrile-Polyethyleneoxide Hollow Fiber Membrane Developed for Designing an Antithrombogenic Continuous Ultrafiltration System
| Autor: | Tetsunosuke Kunitomo, Hiroyuki Sugaya, Masaaki Arakawa, Ikuo Aoike, Yasushi Sizuki, Takayuki Takeyama, Fumitake Gejyo, Ryozo Terada |
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| Rok vydání: | 2008 |
| Předmět: |
Materials science
medicine.medical_treatment Acrylic Resins Biomedical Engineering Medicine (miscellaneous) Biocompatible Materials Bioengineering Electrolyte Polyethylene Glycols Biomaterials chemistry.chemical_compound Dogs Hemofiltration medicine Animals Humans Polyacrylonitrile Membranes Artificial Thrombosis Equipment Design General Medicine Acute Kidney Injury Ultrafiltration (renal) Membrane Mean blood pressure chemistry Hollow fiber membrane Systemic anticoagulation Biomedical engineering |
| Zdroj: | Artificial Organs. 16:146-150 |
| ISSN: | 1525-1594 0160-564X |
| DOI: | 10.1111/j.1525-1594.1992.tb00285.x |
| Popis: | To develop a continuous arteriovenous hemo-filtration (CAVH) system, which does not need systemic anticoagulation, for patients of acute renal failure having bleeding tendencies, a totally antithrombogenic continuous ultrafiltration system (ACUS) was designed, which consists of an antithrombogenic polyacrylonitrile-poly-ethyleneoxide (PAN-PEO) hollow fiber membrane and ionically heparin-bound catheter, tubing, and module header. Antithrombogenicity of PAN-PEO membrane, which occupies more than 90% of total inner surface area of ACUS, was considered to be due to highly concentrated PEO near the inner surfaceaof the membrane and the finely dispersed (less than 500 A) microstructure of the inner surface. ACUS was applied to 24 patients without systemic anticoagulation, and one filter worked for an average of 32 h without deteriorating their bleeding tendencies. Any significant changes in major parameters of biocompat-ibility during those treatments were not observed. More than 200 ml/h of ultrafiltrate was obtained even under very low mean blood pressure, less than 70 mm Hg. Based upon these results, ACUS was concluded to be suitable for mild and sustained treatment to control fluid and electrolyte balance in patients of acute renal failure with bleeding complications. |
| Databáze: | OpenAIRE |
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