Effects of Nefopam on Streptozotocin-Induced Diabetic Neuropathic Pain in Rats
| Autor: | Ji Hoon Sim, Ho Soo Ahn, Jin Sun Kim, Myong-Hwan Karm, Jeong Gil Leem, Jae Sik Nam, Seong-Soo Choi, Yu Seon Cheong |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
TRPM8
endocrine system diseases business.industry Analgesic Chronic pain Pharmacology medicine.disease Streptozotocin streptozotocin TRPA1 Anesthesiology and Pain Medicine Nociception Nefopam Allodynia Anesthesia painful diabetic neuropathy Neuropathic pain medicine Original Article nefopam medicine.symptom business allodynia medicine.drug |
| Zdroj: | The Korean Journal of Pain |
| ISSN: | 2093-0569 2005-9159 |
| Popis: | Background: Nefopam is a centrally acting non-opioid analgesic agent. Its analgesic properties may be related to the inhibitions of monoamine reuptake and the N-methyl-D-aspartate (NMDA) receptor. The antinociceptive effect of nefopam has been shown in animal models of acute and chronic pain and in humans. However, the effect of nefopam on diabetic neuropathic pain is unclear. Therefore, we investigated the preventive effect of nefopam on diabetic neuropathic pain induced by streptozotocin (STZ) in rats. Methods: Pretreatment with nefopam (30 mg/kg) was performed intraperitoneally 30 min prior to an intraperitoneal injection of STZ (60 mg/kg). Mechanical and cold allodynia were tested before, and 1 to 4 weeks after drug administration. Thermal hyperalgesia was also investigated. In addition, the transient receptor potential ankyrin 1 (TRPA1) and TRP melastatin 8 (TRPM8) expression levels in the dorsal root ganglion (DRG) were evaluated. Results: Pretreatment with nefopam significantly inhibited STZ-induced mechanical and cold allodynia, but not thermal hyperalgesia. The STZ injection increased TRPM8, but not TRPA1, expression levels in DRG neurons. Pretreatment with nefopam decreased STZ-induced TRPM8 expression levels in the DRG. Conclusions: These results demonstrate that a nefopam pretreatment has strong antiallodynic effects on STZ-induced diabetic rats, which may be associated with TRPM8 located in the DRG. (Korean J Pain 2014; 27: 326-333) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|