Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens
| Autor: | Taís Maria Bauab, Paulo Takeo Sano, Felipe Hilário, Lourdes Campaner dos Santos, Marcelo R. de Amorim |
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| Přispěvatelé: | Instituto de Química, Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Chromatography
antimicrobial activity 010405 organic chemistry Dimer Ethyl acetate ANTIFÚNGICOS Human pathogen General Chemistry Antimicrobial medicine.disease_cause Mass spectrometry Paepalanthus planifolius 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Minimum inhibitory concentration chemistry.chemical_compound chemistry Staphylococcus aureus medicine naphthopyranone |
| Zdroj: | Journal of the Brazilian Chemical Society v.29 n.4 2018 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Journal of the Brazilian Chemical Society, Volume: 29, Issue: 4, Pages: 766-774, Published: APR 2018 Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0103-5053 |
| Popis: | Made available in DSpace on 2018-12-11T17:17:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-04-01. Added 1 bitstream(s) on 2019-10-09T18:31:29Z : No. of bitstreams: 1 S0103-50532018000400766.pdf: 424586 bytes, checksum: ce2891dd53981969a190103d205f3b1b (MD5) The chemical investigation of ethyl acetate extract from Paepalanthus planifolius capitula resulted in the identification of 1H-naphtho[2,3-c]pyran-1-one,9-[(6-O β D glucopyranosyl- β D glucopyranosyl)oxy]-3,4-dihydro-10-hydroxy-7-methoxy-3-methyl, semi-vioxanthin 9 O β D glucopyranoside, toralactone-9-O-β-D-glucopyranoside, paepalantine- 9 O β D glucopyranoside, semi-vioxanthin, 1H-naphtho[2,3-c]pyran-1-one,3,4-dihydro- 9,10 dihydroxy-5,7-dimethoxy-3-methyl, vioxanthin and paepalantine dimer, and also the isolation and identification of a new naphthopyranone dimer named planifoliusin A. The chemical structures of two compounds were elucidated by performing spectroscopic 1D and 2D nuclear magnetic resonance (NMR) experiments and spectrometric HRMS (high-resolution mass spectrometry) analysis. Other six naphthopyranone dimers were proposed by MS fragmentation patterns. The minimum inhibitory concentration (MIC) values for vioxanthin (7.8 μg mL-1), planifoliusin A (15.6 μg mL-1) and the ethyl acetate extract (31.2 μg mL-1) showed antimicrobial activity against Staphylococcus aureus (ATCC 25923). Departamento de Química Orgânica Instituto de Química Departamento de Ciências Biológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) Departamento de Botânica Instituto de Biociências Universidade de São Paulo (USP) Departamento de Ciências Biológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) |
| Databáze: | OpenAIRE |
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