Clinical utility of the ASDAS index in comparison with BASDAI in patients with ankylosing spondylitis (Axis Study)
| Autor: | Eduardo Collantes Estévez, Julio Medina Luezas, Xavier Juanola Roura, Cesar Fisac, Virginia Carrasco Benitez, José Rosas, Agustí Sellas i Fernandez, Alberto Alonso Ruiz, Miguel Ángel Abad Hernández |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Adult Male medicine.medical_specialty Psychometrics Immunology Patient assessment Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Rheumatology Criterion validity medicine Immunology and Allergy Humans In patient Spondylitis Ankylosing Prospective Studies Sensitivity to change BASDAI 030203 arthritis & rheumatology Ankylosing spondylitis business.industry Construct validity Middle Aged medicine.disease 030104 developmental biology Physical therapy Observational study Female business |
| Zdroj: | Rheumatology international. 37(11) |
| ISSN: | 1437-160X |
| Popis: | The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observational study in patients with AS (NY-modified criteria) from 23 Spanish centers. Physical and analytical data; global, lumbar, and nocturnal pain; ASDAS, BASDAI and minimally acceptable clinical status (PASS) were collected. Psychometric characteristics of both indexes were analyzed: construct validity (convergent and divergent), discriminant capacity, criterion validity (global physician and patient assessment), and sensitivity to change. The study involved 127 patients (19.7% attrition). Both BASDAI and ASDAS showed a higher correlation with patient’s global assessment (r = 0.76 and 0.70, respectively) than with physician’s global assessment (r = 0.67 and 0.57). Both scores allowed discriminating patients with an acceptable clinical status, although BASDAI to a greater extent than ASDAS (Cohen δ 1.72 vs 0.88 for the medical PASS). Both scores showed sensitivity to change in patients who changed from an unacceptable symptomatic state to acceptable according to PASS criteria (physician and patient) and by BASDAI 50 response criteria (Cohen δ > 0.80). BASDAI showed better criterion validity than ASDAS, both for the patient PASS (AUC 0.85 vs 0.79) and for the physician’s (AUC 0.90 vs 0.79). ASDAS shows adequate performance for disease activity in patients with AS; however, in this study, its psychometric properties do not present advantages over BASDAI in terms of criterion validity, sensitivity to change or discriminative capacity; replacement of BASDAI by ASDAS is not supported by the data. |
| Databáze: | OpenAIRE |
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