Gonadotropin-releasing hormone agonist and human menopausal gonadotropin (hMG) short protocol, but not hMG alone, rescues the corpus luteum from the preceding cycle
| Autor: | Gerson Weiss, V. Daniel Castracane, Laura T. Goldsmith, Cecilia L. Schmidt-Sarosi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.medical_specialty Menotropins medicine.drug_class medicine.medical_treatment media_common.quotation_subject Controlled ovarian hyperstimulation Luteal phase Biology Ovulation Induction Corpus Luteum Gonadotropin-releasing hormone agonist Internal medicine medicine Humans Ovulation Progesterone media_common Relaxin Estradiol Obstetrics and Gynecology Endocrinology medicine.anatomical_structure Reproductive Medicine Ovulation induction Female Gonadotropin Leuprolide Corpus luteum hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and sterility. 66(4) |
| ISSN: | 0015-0282 |
| Popis: | Objective To determine whether ovulation induction regimens, particularly the short protocol, has an effect on the corpus luteum (CL) from the previous cycle. Design Infertility patients were followed in an academic research environment. Patients were treated with either the short protocol (GnRH agonist [GnRH-a] and hMG) or hMG alone in a controlled ovarian hyperstimulation cycle. Setting Infertility center in academic setting. Patients Patients requiring ovulation induction. Interventions The blood samples were drawn on day 2 or 3 as a baseline before initiation of any treatments, generally on day 5 and usually every other day thereafter until ovulation. Serum P, E 2 , and relaxin were determined. Main Outcome Measures Serum P, E 2 , and relaxin. Results Patients receiving hMG alone showed no change in serum P levels in the first few days of treatment whereas most short-protocol patients (18/30; 60%) showed an increase of P within 3days of the initiation of treatment. The increase in P almost always was associated with an increase in relaxin as a marker of the luteal production of this P. Conclusion The short protocol with its flare of gonadotropins is able to stimulate the CL from the previous cycle, resulting in an early increase in P that comes from the CL as indicated by its association with an increased relaxin in the same subjects. |
| Databáze: | OpenAIRE |
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