The association of plasma peroxiredoxin 3 with insulin in pregnant women
| Autor: | Li Wang, Jingmin Li, Tian-Tian Li, Lianqin Li, Ran-Ran Liu, Xiaoyan Li, Jun-Mei Hao, Ai-Qun Yu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Peroxiredoxin III Placenta medicine.medical_treatment Biophysics Mitochondrion medicine.disease_cause Biochemistry Cell Line Islets of Langerhans Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Pregnancy Internal medicine medicine Animals Humans Insulin Hydrogen peroxide Molecular Biology Term pregnancy business.industry High insulin Cell Biology medicine.disease 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Female business Peroxiredoxin Oxidative stress |
| Zdroj: | Biochemical and Biophysical Research Communications. 508:805-810 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2018.12.021 |
| Popis: | Peroxiredoxin 3 (PRX3) is predominantly located in mitochondria and plays a major role in scavenging hydrogen peroxide of mitochondria. In the present study, we detected plasma PRX3 in pregnant women receiving oral glucose tolerance test at 24–28 gestational weeks. Plasma PRX3 was significantly increased about 1 h later than insulin secretion. In vitro detection of PRX3 in mouse islet cells showed up-regulation by more than 2-fold at 1 h and reached its top at 2 h of glucose stimulation, and the PRX3 level in cultured mediums was concomitantly elevated in a glucose concentration-dependent manner. In addition, both fasting plasma insulin and PRX3 were significantly higher in the subjects of term pregnancy as compared to that at 24–28 gestational weeks, and there was a positive correlation between plasma PRX3 and insulin. Our results indicate that PRX3 plays an active role in the response to insulin release. The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. |
| Databáze: | OpenAIRE |
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