Extraskeletal Ewing sarcoma of the parapharyngeal space with a unique translocation, t(19;22) (q13.4;q12.2)
| Autor: | Samer N. Khader, Bradley A. Schiff, Mark J. Suhrland, Esther Adler, K.H. Ramesh, Gloria Ramos-Rivera |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Chromosomal translocation Ewing sarcoma family of tumors medicine.disease Pathology and Forensic Medicine 03 medical and health sciences Parapharyngeal space t(19 22)(q13.4 q12.2) 0302 clinical medicine 030220 oncology & carcinogenesis Extraskeletal Ewing sarcoma medicine lcsh:Pathology Sarcoma 030223 otorhinolaryngology business lcsh:RB1-214 |
| Zdroj: | Human Pathology: Case Reports, Vol 4, Iss C, Pp 38-41 (2016) |
| ISSN: | 2214-3300 |
| DOI: | 10.1016/j.ehpc.2015.07.003 |
| Popis: | Extraskeletal Ewing sarcomas of the parapharyngeal space are extremely rare. It has been documented that Ewing sarcomas are morphologically and molecularly indistinguishable regardless of the tissue of origin. Around 85% of Ewing sarcomas are associated with translocation t(11;22)(q24.1;12.2) generating the EWSR1–FLI1 fusion oncoprotein. We report a case of an extraskeletal Ewing sarcoma arising in the parapharyngeal space with a unique translocation: t(19; 22) (q13.4;q12.2). To our knowledge this is the first case of an extraskeletal Ewing sarcoma exhibiting this translocation. |
| Databáze: | OpenAIRE |
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