NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness
| Autor: | Julien Gaudias, Elena Tolmacheva, Nigel C. Jones, Terence J. O'Brien, Michael R. Salzberg, Tahir Hakami, Didier Pinault, Jospeh Chaumont |
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| Přispěvatelé: | Pinault, Didier, Department of Medicine, University of Melbourne-Royal Melbourne Hospital, Physiopathologie clinique et expérimentale de la schizophrénie, Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Psychiatry [Melbourne], Melbourne Medical School [Melbourne], Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne-Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne, Inserm, Université de Strasbourg, NH&MRC (Australia) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Hippocampus
lcsh:Medicine Local field potential Striatum limbic system Neuroscience/Motor Systems MESH: Animals EEG Prefrontal cortex lcsh:Science MK-801 Multidisciplinary Neuroscience/Behavioral Neuroscience musculoskeletal neural and ocular physiology MESH: Excitatory Amino Acid Antagonists Pharmacology/Drug Interactions medicine.anatomical_structure Mental Health Mental Health/Substance Abuse Anesthesia schizophrenia [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Ketamine Locomotion Research Article noise MESH: Rats Consciousness Thalamus MESH: Locomotion Nucleus accumbens Amygdala Receptors N-Methyl-D-Aspartate MESH: Consciousness medicine Neuroscience/Neuronal Signaling Mechanisms Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Mental Health/Schizophrenia and Other Psychoses MESH: Receptors N-Methyl-D-Aspartate business.industry Neuroscience/Sensory Systems lcsh:R MESH: Ketamine MESH: Dizocilpine Maleate Rats Electrophysiology lcsh:Q Dizocilpine Maleate business Neuroscience Excitatory Amino Acid Antagonists |
| Zdroj: | PLoS ONE, Vol 4, Iss 8, p e6755 (2009) PLoS ONE PLoS ONE, Public Library of Science, 2009, 4 (8), pp.e6755. ⟨10.1371/journal.pone.0006755⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0006755⟩ |
| Popis: | BACKGROUND: The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms. In conscious rats, they produce an abnormal behavior associated with a peculiar brain state characterized by increased synchronization in ongoing gamma (30-80 Hz) oscillations in the frontoparietal (sensorimotor) electrocorticogram (ECoG). This study investigated whether NMDAr antagonists-induced aberrant gamma oscillations are correlated with locomotion and dependent on hyperlocomotion-related sensorimotor processing. This also implied to explore the contribution of intracortical and subcortical networks in the generation of these pathophysiological ECoG gamma oscillations. METHODOLOGY/PRINCIPAL FINDINGS: Quantitative locomotion data collected with a computer-assisted video tracking system in combination with ECoG revealed that ketamine and MK-801 induce highly correlated hyperlocomotion and aberrant gamma oscillations. This abnormal gamma hyperactivity was recorded over the frontal, parietal and occipital cortices. ECoG conducted under diverse consciousness states (with diverse anesthetics) revealed that NMDAr antagonists dramatically increase the power of basal gamma oscillations. Paired ECoG and intracortical local field potential recordings showed that the ECoG mainly reflects gamma oscillations recorded in underlying intracortical networks. In addition, multisite recordings revealed that NMDAr antagonists dramatically enhance the amount of ongoing gamma oscillations in multiple cortical and subcortical structures, including the prefrontal cortex, accumbens, amygdala, basalis, hippocampus, striatum and thalamus. CONCLUSIONS/SIGNIFICANCE: NMDAr antagonists acutely produces, in the rodent CNS, generalized aberrant gamma oscillations, which are not dependent on hyperlocomotion-related brain state or conscious sensorimotor processing. These findings suggest that NMDAr hypofunction-related generalized gamma hypersynchronies represent an aberrant diffuse network noise, a potential electrophysiological correlate of a psychotic-like state. Such generalized noise might cause dysfunction of brain operations, including the impairments in cognition and sensorimotor integration seen in schizophrenia. |
| Databáze: | OpenAIRE |
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