Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
| Autor: | Peter Haas, Pierre Quartier, NM Wulffraat, D. M. C. Brinkman, Matthew P. Frosch, Johannes Roth, I. M. de Kleer, Thomas J. Vogl, Wietse Kuis |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Myeloid Adolescent medicine.medical_treatment Immunology Arthritis Enzyme-Linked Immunosorbent Assay Hematopoietic stem cell transplantation Blood Sedimentation Transplantation Autologous General Biochemistry Genetics and Molecular Biology Autoimmune Diseases Leukocyte Count Autologous stem-cell transplantation Rheumatology Recurrence medicine Immunology and Allergy Calgranulin B Humans Calgranulin A Child Phagocytes medicine.diagnostic_test business.industry Hematopoietic Stem Cell Transplantation medicine.disease Arthritis Juvenile Transplantation Extended Report medicine.anatomical_structure Rheumatoid arthritis Erythrocyte sedimentation rate Child Preschool Female business Juvenile rheumatoid arthritis |
| Zdroj: | Annals of the rheumatic diseases. 62(3) |
| ISSN: | 0003-4967 |
| Popis: | Objectives: To determine whether myeloid related proteins (MRP8/MRP14), a complex of two S100 proteins related to neutrophil and monocyte activation, might be used as a marker for disease activity, and as an early indicator of relapse in juvenile idiopathic arthritis. Patients and methods: A group of 12 patients who underwent an autologous haematopoietic stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA) were studied. MRP8/MRP14 serum concentrations were determined by a sandwich enzyme linked immunosorbent assay (ELISA) as described. Improvement from baseline was described by a definition of improvement employing a core set of criteria as detailed previously by Giannini. Results: After ASCT, MRP8/MRP14 serum concentrations in JIA showed a positive correlation with the Child Health Assessment Questionnaire (CHAQ; r=0.80) and erythrocyte sedimentation rate (r=0.45), but not with the total leucocyte count (r=0.26). Mean MRP8/MRP14 serum concentrations dropped markedly in the first three months after ASCT (p=0.0039) and clinical parameters of disease activity such as CHAQ markedly improved (p=0.0039). During a transient relapse there was an increase in MRP8/MRP14. Conclusions: MRP8/MRP14 serum concentration can be used as a marker for disease activity in patients who receive an ASCT for refractory JIA. This indicates a role of macrophage activation in the pathogenesis of JIA. The occurrence of MAS in three patients in this study was not preceded by significant changes in MRP8/MRP14 concentration. |
| Databáze: | OpenAIRE |
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