25-Vitamin D levels in chronic hepatitis C infection: association with cirrhosis and sustained virologic response
| Autor: | David W. Backstedt, Myunghan Choi, Mark R. Pedersen, Anil B. Seetharam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Bilirubin vitamin D Gastroenterology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound Liver disease 0302 clinical medicine direct acting antiviral Internal medicine Biopsy Vitamin D and neurology Medicine Blood test medicine.diagnostic_test business.industry sustained virologic response Hepatitis C medicine.disease 25-OH vitamin D Endocrinology chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Original Article business |
| Zdroj: | Annals of Gastroenterology |
| ISSN: | 1792-7463 1108-7471 |
| Popis: | Background Low serum 25-Vitamin D levels are associated with advanced fibrosis in hepatitis C infection. Vitamin D supplementation has been hypothesized to augment response rates to interferon-based therapy. To date, no investigation has evaluated vitamin D levels during directacting antiviral therapy. We aimed to evaluate the prevalence of vitamin D deficiency in cirrhotic and non-cirrhotic cohorts, the predictive value of pretreatment levels for a sustained virologic response, and the changes in 25-OH vitamin D levels during direct-acting antiviral therapy. Methods Two hundred eighteen patients with chronic hepatitis C who completed directacting antiviral therapy were consecutively enrolled. Vitamin D levels were measured using chemiluminescence immunoassay, prior to initiation and at completion of therapy. Advanced liver fibrosis (cirrhosis) was determined by biopsy, FibroSURE blood test, or imaging. Results A sustained virologic response was achieved in 79% (n=172) of patients, with 19% (n=44) relapsing. A total of 123 (56.4%) patients were cirrhotic. The prevalence of Vitamin D deficiency (10-20 ng/mL) and severe deficiency ( |
| Databáze: | OpenAIRE |
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