Decreased intramuscular calcium hydroxyapatite implant resorption in a murine model of osteoporosis
| Autor: | Derrick R. Randall, Nogah Nativ-Zeltzer, Steve Tinling, Daniel J. Cates, Peter C. Belafsky |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Ovariectomy Osteoporosis chemistry.chemical_element Calcium Injections Rats Sprague-Dawley 03 medical and health sciences Internal medicine medicine Animals Prospective Studies Muscle Skeletal Drug Implants business.industry Oophorectomy medicine.disease Resorption Rats Disease Models Animal 030104 developmental biology Endocrinology Durapatite Otorhinolaryngology chemistry Thigh Estrogen Liberation Female Implant business Risedronic Acid Hormone |
| Zdroj: | The Laryngoscope. 128(11) |
| ISSN: | 1531-4995 |
| Popis: | Author(s): Randall, Derrick R; Nativ-Zeltzer, Nogah; Cates, Daniel J; Tinling, Steve P; Belafsky, Peter C | Abstract: ObjectiveCalcium hydroxyapatite (CaHA) is a common material for vocal fold injection augmentation. Durability is variable, and factors involved in implant longevity are not understood. Animal models of osteoporosis show decreased bone density and increased mineral liberation, suggesting CaHA retention may be altered in these conditions.Study designProspective murine investigation.MethodsFourteen skeletally mature, 10-month-old female Sprague-Dewley rats were treated by one of three interventions: oophorectomy, laparotomy without oophorectomy (sham), or monthly risedronate injection (90 μg/kg, subcutaneous). CaHA was implanted into the right lateral thigh muscle in all animals at the time of procedure or first risedronate injection. After 17 weeks, all rats were sacrificed, and the residual CaHA isolated from excised lateral thigh muscle through incubation in a 900 °C calcinator for 9 hours.ResultsMean CaHA mass remaining in the oophorectomy group was 65.9 (standard deviation ± 16.1) mg, compared to 44.4 ± 10.0 mg CaHA in the risedronate group and 48.6 ± 7.5 mg in the sham group. One-way analysis of variance found a statistically significant difference between the oophorectomy and risedronate groups but not between the sham and other groups, F(2,11) = 4.404, P = 0.039.ConclusionPersistent estrogen deficiency in a murine model of osteoporosis demonstrated decreased rate of CaHA resorption. This suggests that hormone alterations associated with osteoporosis may alter the longevity of CaHA implant resorption through an uncertain mechanism.Level of evidenceNA. Laryngoscope, 2576-2580, 2018. |
| Databáze: | OpenAIRE |
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