The cells of monocyte-macrophage lineage in mice with the 2-month polyethylene implantation
| Autor: | Henryka Dlugonska, Wiesława Rudnicka, Barbara Różalska, Aleksandra Burow, Åsa Ljungh, B Paziak-Domanska |
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| Rok vydání: | 1996 |
| Předmět: |
Lineage (genetic)
medicine.drug_class Immunology Biocompatible Materials Bone Marrow Cells Monoclonal antibody Monocytes Mice Peritoneum Bone Marrow medicine Immunology and Allergy Monocytes macrophages Animals Monocytoid Cells Peritoneal Cavity Cells Cultured biology Chemistry Macrophages Cell Differentiation Prostheses and Implants Molecular biology Fibronectin Mice Inbred C57BL medicine.anatomical_structure biology.protein Female Bone marrow Polyethylenes |
| Zdroj: | Immunology letters. 49(1-2) |
| ISSN: | 0165-2478 |
| Popis: | End-point-attached heparinized polyethylene (H-PE) was implanted for 2 months into the peritoneum of C57B1/6 mice. The proliferation of bone marrow cells (BMCs) from implanted and non-implanted mice was investigated in M-CSF supplemented medium, in the presence or absence of macrophage-specific monoclonal antibodies (mAbs). The mAb HC 7.67.B, recognizing a surface determinant on immature monocytoid cells, inhibited the proliferation of BMCs from H-PE implanted mice without any influence on the proliferation of BMCs from non-implanted animals. The peritoneal macrophages from H-PE implanted mice demonstrated enhanced production of fibronectin (Fn) in comparison to the macrophages from non-implanted animals. Our results suggest changes in the differentiation of murine monocyte-macrophage lineage in the mice bearing H-PE implants for 2 months. |
| Databáze: | OpenAIRE |
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