The tumorigenicity of 5-azacytidine in the male Fischer rat
| Autor: | Reilly Jg, Brian I. Carr, Steven S. Smith, C. D. Winberg, Riggs Ad |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Skin Neoplasms medicine.drug_class Malignant histiocytosis Azacitidine Biology Methylation Antimetabolite Liver Neoplasms Experimental Testicular Neoplasms medicine Animals Lymphatic Diseases Carcinogen Bronchus Acute leukemia Leukemia Experimental DNA Neoplasms Experimental General Medicine medicine.disease Kidney Neoplasms Rats Inbred F344 Rats Lymphatic disease medicine.anatomical_structure Toxicity medicine.drug |
| Zdroj: | Carcinogenesis. 5:1583-1590 |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | 5-Azacytidine was administered to young adult male Fischer rats. Tumors were found in 31 out of 70 rats that had received 5-azacytidine and survived 18 months from the start of the experiment. Several rats had multiple primary tumors. In the rats that were tested for complete carcinogenicity a variety of tumor types was found. These included acute leukemia and malignant reticuloendotheliosis, and tumors of the testis, skin, and bronchus. No hepatic tumors were found in the group that was tested for hepatic tumor initiation. Hepatocellular carcinomas were found only in the group that was examined for hepatic tumor promotion by receiving a prior initiating dose of diethylnitrosamine. No tumors were found in the age controls. Thus, in these initial experiments, 5-azacytidine appeared to be a complete carcinogen, inducing tumors in several organs, and a tumor promoter but not a complete carcinogen for the liver. |
| Databáze: | OpenAIRE |
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