The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
| Autor: | Malcolm Campbell, Rosemary Huntriss, Carol Bedwell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Population Medicine (miscellaneous) 030209 endocrinology & metabolism Blood Pressure Type 2 diabetes 03 medical and health sciences Diet Carbohydrate-Restricted 0302 clinical medicine Diabetes management Statistical significance Internal medicine Diabetes mellitus Weight Loss medicine Humans 030212 general & internal medicine Cluster randomised controlled trial education Randomized Controlled Trials as Topic Glycated Hemoglobin education.field_of_study Nutrition and Dietetics business.industry medicine.disease Lipids Blood pressure Treatment Outcome Diabetes Mellitus Type 2 Meta-analysis Patient Compliance business |
| Zdroj: | Huntriss, R, Campbell, M & Bedwell, C 2017, ' The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials ', European Journal of Clinical Nutrition . https://doi.org/10.1038/s41430-017-0019-4 |
| Popis: | Recently, the role of a low-carbohydrate diet in diabetes management has generated interest with claims being made regarding its superiority over the traditional high-carbohydrate, low-fat dietary approach. This systematic review and meta-analysis evaluated the interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes. Randomised controlled trials were searched for which included adults with type 2 diabetes aged 18 years or more. The intervention was a low-carbohydrate diet as defined by the author compared to a control group of usual care. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, ISRCTN, ProQuest and opengrey.eu were searched. Independent experts were contacted and reference lists of selected papers were checked. Results were analysed descriptively and meta-analyses were completed to include trials that presented data at 1 year. Eighteen studies (n = 2204) were eligible for inclusion within the systematic review. The definition of a low-carbohydrate diet varied. At trial end, the descriptive analysis suggested that the low-carbohydrate intervention arm (LCIA) may promote favourable outcomes in terms of HbA1c, triglycerides and HDL cholesterol. The LCIA demonstrated reduced requirements for diabetes medication, which may have reduced the observed benefit of dietary carbohydrate restriction on HbA1c. Seven studies provided data to be included in the meta-analyses at 1 year. The meta-analyses showed statistical significance in favour of the LCIA for HbA1c (estimated effect = −0.28%, 95% CI −0.53 to −0.02, p = 0.03; χ 2 = 13.15, df = 6, p = 0.03; I 2 = 54%), HDL cholesterol (estimated effect = 0.06 mmol/L, 95% CI 0.04–0.09, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|