Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients
| Autor: | Masayoshi Tani, Kenji Fujiwara, Tomoaki Tomiya, Shigeki Hayashi, Shinwa Yamada, Noritsugu Umeda |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Cirrhosis medicine.medical_treatment Biology Leukocyte Count White blood cell Internal medicine medicine Hepatectomy Humans Hepatology Hepatocyte Growth Factor Growth factor Gastroenterology Alanine Transaminase Bilirubin Middle Aged medicine.disease Liver regeneration Liver Regeneration C-Reactive Protein medicine.anatomical_structure Endocrinology Liver Hepatocyte Regression Analysis Female Hepatocyte growth factor medicine.symptom medicine.drug |
| Zdroj: | Gastroenterology. 103:1621-1624 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/0016-5085(92)91186-8 |
| Popis: | Serum hepatocyte growth factor levels were measured in hepatectomized and nonhepatectomized surgical patients. The levels were significantly increased and reached a maximum within 7 days after surgery in both groups, returning to preoperative levels 28 days after partial hepatectomy and 7 days after other operations. Multiple regression analysis showed that such maximal hepatocyte growth factor levels were significantly related to having liver cirrhosis and postoperative maximal serum total bilirubin and alanine aminotransferase levels and peripheral white blood cell counts in the hepatectomized group and to postoperative maximal peripheral white blood cell counts and serum C-reactive protein levels in the nonhepatectomized group. However, the levels showed no relation to the resected liver volume and increment of the remaining liver volume 28 days after partial hepatectomy. It is concluded that serum hepatocyte growth factor levels were increased after partial hepatectomy in association with hepatocellular dysfunction and necrosis and systemic inflammation. It is unlikely that the increase was related to liver regeneration. |
| Databáze: | OpenAIRE |
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