Red Cell Indices and Functions Differentiating Patients with the β-Thalassaemia Trait from those with Iron Deficiency Anaemia
| Autor: | Vahap Okan, A Cigiloglu, S Cifci, Mustafa Pehlivan, Mehmet Yilmaz |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Erythrocyte Indices
Male medicine.medical_specialty Pediatrics Anemia Youden's J statistic Diagnostic accuracy β thalassaemia Biochemistry Gastroenterology Young Adult Internal medicine Haemoglobin G Humans Medicine Aged Aged 80 and over Anemia Iron-Deficiency business.industry Erythrocyte indices RED-CELL INDICES beta-Thalassemia Biochemistry (medical) Cell Biology General Medicine Iron deficiency Middle Aged medicine.disease Female business |
| Zdroj: | Journal of International Medical Research. 37:25-30 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000903700103 |
| Popis: | This study examined the diagnostic accuracy of nine indices to discriminate between patients with mild-to-moderate (haemoglobin 8.5 − 11 g/dl) or moderate-to-severe (haemoglobin < 8.5 g/dl) iron deficiency anaemia (IDA) from those with β-thalassaemia (β-TT) ( n = 100 per group). Indices examined were red blood cell (RBC) count, RBC distribution width (RDW), Mentzer index (MI), Shine and Lal index (S&L), England and Fraser index (E&F), Srivastava index (S), Green and King index (G&K), RDW index (RDWI), and Ricerca index (R). Index sensitivity, specificity, and positive and negative prognostic values were examined. Youden's indices were calculated and showed: S&L > G&K > E&F > RBC = RDWI > MI > S > R > RDW to differentiate between β-TT and mild-to-moderate IDA; and S&L > G&K > E&F = RDWI > RBC > R > MI > S > RDW to differentiate between β-TT or moderate-to-severe IDA. For both groups, S&L and G&K offered the best discrimination and RDW the worst. S&L showed the highest Youden index for β-TT and IDA discrimination, but sensitivity and specificity were not 100%. In both mild and severe IDA, the S&L index may be used to differentiate cases of β-TT from IDA cases, but large clinical trials are needed to explore this further. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|