Transposable element regulation and expression in cancer
| Autor: | Erin E. Grundy, Noor Diab, Katherine B. Chiappinelli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Transposable element Carcinogenesis Cellular differentiation Human Embryonic Stem Cells Antineoplastic Agents Biology medicine.disease_cause Biochemistry Genome Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Humans Gene Silencing Epigenetics Molecular Biology food and beverages Cancer Cell Differentiation Cell Biology DNA Methylation medicine.disease Embryonic stem cell Cell biology Gene Expression Regulation Neoplastic Mutagenesis Insertional Long Interspersed Nucleotide Elements 030104 developmental biology 030220 oncology & carcinogenesis DNA Transposable Elements Human genome Tumor Suppressor Protein p53 Protein Processing Post-Translational Metabolic Networks and Pathways |
| Zdroj: | The FEBS Journal. 289:1160-1179 |
| ISSN: | 1742-4658 1742-464X |
| DOI: | 10.1111/febs.15722 |
| Popis: | Approximately 45% of the human genome is composed of transposable elements (TEs). Expression of these elements is tightly regulated during normal development. TEs may be expressed at high levels in embryonic stem cells but are epigenetically silenced in terminally differentiated cells. As part of the global "epigenetic dysregulation" that cells undergo during transformation from normal to cancer, TEs can lose epigenetic silencing and become transcribed, and, in some cases, active. Here, we summarize recent advances detailing the consequences of TE activation in cancer and describe how these understudied residents of our genome can both aid tumorigenesis and potentially be harnessed for anti-cancer therapies. |
| Databáze: | OpenAIRE |
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