Pathological crystallization of human immunoglobulins

Autor:	Ying Wang, Nikhil C. Munshi, Kenneth C. Anderson, Aleksey Lomakin, Teru Hideshima, Paul G. Richardson, Olutayo Ogun, George B. Benedek, Jacob P. Laubach
Rok vydání:	2012
Předmět:	Supersaturation Multidisciplinary Chromatography Chemistry Biological Sciences Buffers Hydrogen-Ion Concentration Crystallography X-Ray medicine.disease Cryoglobulinemia Cryoglobulins law.invention Immune system Solubility Biochemistry In vivo law medicine Humans Crystallization Multiple myeloma
Zdroj:	Proceedings of the National Academy of Sciences. 109:13359-13361
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.1211723109
Popis:	Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaefa652b84b882d3ebcec7a56137d https://doi.org/10.1073/pnas.1211723109 Zobrazit plný text záznamu