How Hormones Influence Composition and Physiological Function of the Brain-Blood Barrier

Autor:	Richard Hampl, Lucie Sosvorova, M Bičíková
Rok vydání:	2015
Předmět:	Tight junction Physiology Chemistry Brain Endothelial Cells General Medicine Blood–brain barrier Hormones Transport protein Cell biology Protein Transport medicine.anatomical_structure Blood-Brain Barrier Paracellular transport medicine Animals Humans Transcellular Receptor Intracellular Hormone
Zdroj:	Scopus-Elsevier
ISSN:	1802-9973 0862-8408
Popis:	Hormones exert many actions in the brain. Their access and effects in the brain are regulated by the blood-brain barrier (BBB). Hormones as other substances may enter the brain and vice versa either by paracellular way requiring breaching tight junctions stitching the endothelial cells composing the BBB, or by passage through the cells (transcellular way). Hormones influence both ways through their receptors, both membrane and intracellular, present on/in the BBB. In the review the main examples are outlined how hormones influence the expression and function of proteins forming the tight junctions, as well as how they regulate expression and function of major protein transporters mediating transport of various substances including hormone themselves.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a9bb252801a6baa55811029f19b3cd https://doi.org/10.33549/physiolres.933110 Zobrazit plný text záznamu