Polyacetylenes from the leaves of Vernonia scorpioides (Asteraceae) and their antiproliferative and antiherpetic activities
| Autor: | Daniel F. Coimbra, Andersson Barison, Luiz A.E. Pollo, Jadel M. Kratz, Caroline Rigotto, Andrea S. Leite, Giovanni F. Caramori, Maique W. Biavatti, Cristiane F. Bosi, Cláudia Maria Oliveira Simões, Francinete Ramos Campos, Angelita Nepel, David E. P. Fonseca |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
food.ingredient
Human cell line Plant Science Horticulture Antiviral Agents Biochemistry food Cell Line Tumor Botany Humans Simplexvirus Molecular Biology Inhibitory effect chemistry.chemical_classification Apiaceae Molecular Structure biology Plant Extracts Polyynes Glycoside General Medicine Asteraceae biology.organism_classification Small Cell Lung Carcinoma Plant Leaves chemistry Herb Araliaceae Medicine Traditional Vernonia Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Phytochemistry. 95:375-383 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2013.07.011 |
| Popis: | Polyacetylenes constitute an underexplored and unstable class of compounds that are found mainly in the Apiaceae, Araliaceae and Asteraceae families. Vernonia scorpioides (Lam.) Pers., Asteraceae is a lianous neotropical herb that usually grows in soils that have been deforested and are of poor quality. It is used in folk medicine for the treatment of several skin conditions. This study addresses the characterisation of eight polyacetylenes isolated from the leaves of V. scorpioides. Their structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis. Ab initio calculations including solvent effects were employed to aid the elucidation of the absolute configurations of the compounds. The in vitro antiproliferative and anti-herpetic activities of the polyacetylenes were determined. The isolated compounds presented no inhibitory effect against a human cell line of non-small cell lung cancer, but presented a mild non-selective in vitro antiviral activity, although their corresponding glycosides were inactive. |
| Databáze: | OpenAIRE |
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