Lipids, Lipoproteins, Apolipoproteins, Selected Trace Elements and Minerals in the Serum of Children on Valproic Acid Monotherapy
| Autor: | Theodore Karakonstantakis, George A. Karikas, Kleopatra H. Schulpis, Anastasia Bartzeliotou, Ioannis Papassotiriou, Sophia Georgala, Ino Kanavaki, Elizabeth Demetriou |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Lipoproteins medicine.medical_treatment Toxicology Internal medicine medicine Humans Child Pharmacology Valproic Acid biology medicine.diagnostic_test Chemistry Albumin General Medicine Trace Elements Apolipoproteins Anticonvulsant Endocrinology Biochemistry biology.protein lipids (amino acids peptides and proteins) Liver function Liver function tests Lipid profile medicine.drug Lipoprotein |
| Zdroj: | Basic Toxicology. 98:599-603 |
| ISSN: | 1742-7843 1742-7835 |
| DOI: | 10.1111/j.1742-7843.2006.pto_402.x |
| Popis: | We evaluated the serum levels of lipids, lipoproteins, apolipoproteins, along with a number of minerals and trace elements such as Ca, Mg, Cu and Zn in a group of children after 6 months of valproic acid monotherapy. Thirty patients with seizures, mean age, 9.8+/-2.6 years and 79 healthy children (controls), mean age, 10.9+/-3.2 years, formed the two styd groups. The patient group was treated with valproic acid (27.9+/-14.8 mg/kg/24 hr). Patients underwent clinical and laboratory evaluations including liver function tests, NH3, lipid, mineral and selected trace element levels before and after six months on valproic acid treatment, whereas controls only one evaluation. Liver function data and NH3 levels were found to be elevated in the group of patients, whereas albumin level was reduced. Triglycerides, total cholesterol, HDL-C, apolipoprotein (ApoA)-1, Apo B and Ca concentrations were found relative to control values, LDL-C, VLDL-C, Mg, Cu, Zn, were measured significantly altered (P |
| Databáze: | OpenAIRE |
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