Serum concentrations of psychotropic drugs in neonates as a PROgnOstic Factor for admission to the neonatology ward and withdrawal symptoms
| Autor: | Shirley C.A. Sparla, Mirte M. Malingré, Inge M. Evers, Claire A. I. Stramrood, Paul H.G. Hogeman, Monique M. L. van der Westerlaken, Pieternel Pasker-de Jong, Hans Coppens |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Logistic regression Umbilical cord 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Odds Ratio medicine Humans Pharmacology (medical) 030212 general & internal medicine Neonatology Netherlands Retrospective Studies Psychotropic Drugs business.industry Infant Newborn Retrospective cohort study Odds ratio Fetal Blood Confidence interval Substance Withdrawal Syndrome 030227 psychiatry Hospitalization Psychiatry and Mental health medicine.anatomical_structure Predictive value of tests Female business Cohort study |
| Zdroj: | International Clinical Psychopharmacology. 32:142-146 |
| ISSN: | 0268-1315 |
| DOI: | 10.1097/yic.0000000000000164 |
| Popis: | The aim is to determine whether serum drug concentrations obtained from the neonate's umbilical cord can be used as a prognostic factor for admission to the neonatology ward and the occurrence of withdrawal symptoms. A retrospective observational monocenter cohort study was carried out among pregnant women using psychotropic drugs and their baby. Binary logistic regression was used for the multivariate analysis. Of the 186 neonates included, 22.6% (n=42) were admitted to the neonatology ward, 6.5% (n=12) because of withdrawal. Among women with therapeutic concentrations of psychotropic medication, 22.0% (n=5) of the neonates had withdrawal symptoms. When comparing neonates with therapeutic versus undetectable drug concentrations, an odds ratio of 3.1 (95% confidence interval: 1.1-8.6) was found for admission to the neonatology ward and an odds ratio of 20.5 (95% confidence interval: 2.2-186.1) for the occurrence of withdrawal symptoms. Therapeutic concentrations of psychotropic drugs in neonates' umbilical cord blood correspond with higher odds for admission to the neonatology ward and the occurrence of withdrawal symptoms compared with neonates with undetectable drug concentrations. The measurement of drug concentrations in the neonate may contribute toward the general clinical assessment of the physician to predict the necessity of admission to the neonatology ward and the risk of withdrawal symptoms. |
| Databáze: | OpenAIRE |
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