The IL-17/IL-23 Axis and Its Genetic Contribution to Psoriatic Arthritis
| Autor: | B. Paul Wordsworth, Vivien Xanath Hake, Carlo Selmi, Maria Cristina Carena, Connor Davidson, Matteo Vecellio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Immunology Review urologic and male genital diseases Interleukin-23 Epigenesis Genetic Dactylitis 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Psoriasis medicine Genetic predisposition Interleukin 23 Animals Humans Immunology and Allergy Genetic Predisposition to Disease genetics IL23 psoriatic arthritis 030203 arthritis & rheumatology therapy Oligoarthritis SNPs (single nucleotide polymorphisms) business.industry Arthritis Psoriatic Interleukin-17 IL17 Enthesitis medicine.disease 030104 developmental biology Disease Susceptibility Interleukin 17 medicine.symptom lcsh:RC581-607 business Biomarkers Genome-Wide Association Study Signal Transduction |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2021) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.596086 |
| Popis: | Psoriatic arthritis (PsA) is a chronic inflammatory disease belonging to the family of spondyloarthropathies (SpA). PsA commonly aggravates psoriasis of the skin and frequently manifests as an oligoarthritis with axial skeletal involvement and extraarticular manifestations including dactylitis, enthesitis, and uveitis. The weight of genetic predisposition to psoriasis and PsA is illustrated by the concordance rates in monozygotic twins which clearly demonstrate that genomics is insufficient to induce the clinical phenotype. The association of PsA with several single nucleotide polymorphisms (SNPs) at the IL23R locus and the involvement of Th17 cells in the immunopathogenesis of PsA clearly put the IL-23/IL-17 axis in the spotlight. The IL-23 and IL-17 cytokines have a pivotal role in the chronic inflammation of the synovium in PsA and are also prominent in the skin lesions of those with PsA. In this review, we focus on the genetic association of the IL-23/IL-17 axis with PsA and the contribution of these master cytokines in the pathophysiology of the disease, highlighting the main cell types incriminated in PsA and their specific role in the peripheral blood, lesional skin and joints of patients. We then provide an overview of the approved biologic drugs targeting the IL-23/IL-17 axis and discuss the advantages of genetic stratification to enhance personalized therapies in PsA. |
| Databáze: | OpenAIRE |
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