Prospective clinical and serological follow-up in early childhood reveals a high rate of subclinical RSV infection and a relatively high reinfection rate within the first 3 years of life
| Autor: | Matti Waris, Laura Toivonen, Laura Kakkola, Anna Kutsaya, Ville Peltola, Tamara Teros-Jaakkola, Ilkka Julkunen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Epidemiology Enzyme-Linked Immunosorbent Assay Respiratory Syncytial Virus Infections Antibodies Viral Virus Serology 03 medical and health sciences 0302 clinical medicine Antigen Recurrence Seroepidemiologic Studies Medicine Seroprevalence Humans 030212 general & internal medicine Prospective Studies Respiratory system Asymptomatic Infections Subclinical infection Respiratory tract infections biology business.industry Reverse Transcriptase Polymerase Chain Reaction Infant Original Papers ta3123 030104 developmental biology Infectious Diseases Child Preschool Immunology biology.protein Female Antibody business Follow-Up Studies |
| Zdroj: | Epidemiol Infect |
| ISSN: | 0950-2688 |
| Popis: | SUMMARYChildren encounter repeated respiratory tract infections during their early life. We conducted a prospective clinical and serological follow-up study to estimate the respiratory syncytial virus (RSV) primary infection and reinfection rates in early childhood. Sera were collected from 291 healthy children at the ages of 13, 24 and 36 months and antibody levels against RSV antigens were determined by enzyme immunoassay. The RT–PCR method was also used for identifying the possible presence of RSV in symptomatic patients. At ages 1, 2 and 3 years, 37%, 68% and 86%, respectively, of studied children were seropositive for RSV. In children seropositive at age 1 year, RSV reinfection rate was at least 37%. Only one of reinfected children showed evidence for a third reinfection by age 3 years. Of children who turned RSV seropositive between ages 1 and 2 years, the reinfection rate was 32% during the third year of life. The mean antibody levels at primary infection were very similar in all age groups. The average decrease of antibody levels was 25–30% within a year. In 66 cases RSV infection was identified by RT–PCR. RSV infection rate in early childhood is 86% and reinfection rate is around 35%. This prospective serological follow-up study also provided evidence for the presence of RSV infections in children that did not show clinical signs warranting RSV RNA detection. |
| Databáze: | OpenAIRE |
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