The yak genome and adaptation to life at high altitude
| Autor: | Junyi Wang, Zhaofeng Wang, Shengxiang Zhang, Yan Wang, Yingmei Zhang, Chang-Chang Cao, Hui Ma, Haolong Hou, Jun Wang, Zhiqiang Ye, Tao Ma, Ran Zhou, Jaebum Kim, Guojie Zhang, Qiang Qiu, Jian Wang, Xuetao Zang, Jian Ma, Jinquan Xia, Jian Zhang, Denis M. Larkin, Takahiro Yonezawa, Yongshan Lang, Johannes A. Lenstra, Huanming Yang, Ye Yin, Shengkai Pan, Wubin Qian, Loretta Auvil, Kun Wang, Peng Shi, Zhiyong Huang, Harris A. Lewin, Wenbin Liu, Dawei Zhang, Yang Zhong, Shengguang Liao, Yan Zhang, Quanjun Hu, David Neil Cooper, Ruijun Long, Xiaoju Qian, Masami Hasegawa, Yi Wu, Jianquan Liu, Xu Lu, Lizhong Wang, Boris Capitanu |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Acclimatization
Lineage (evolution) Molecular Sequence Data Biology Genome Evolution Molecular Species Specificity medicine Genetics Animals Gene family Selection Genetic Gene Phylogeny Whole genome sequencing Base Sequence Altitude DNA Hypoxia (medical) Effects of high altitude on humans Multigene Family Cattle Female medicine.symptom Adaptation |
| Zdroj: | Nature Genetics, 44(8), 946. Nature Publishing Group |
| ISSN: | 1061-4036 |
| DOI: | 10.1038/ng.2343 |
| Popis: | Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans. © 2012 Nature America, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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