Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002
| Autor: | Eric S. Edell, Antonio L. Visbal, Marie Christine Aubry, Brent A. Williams, Jason A. Wampfler, James R. Jett, Randolph S. Marks, Ping Yang, Julian R. Molina, Francis C. Nichols |
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| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Adult Male medicine.medical_specialty Lung Neoplasms Adolescent Minnesota Adenocarcinoma Cohort Studies Sex Factors Internal medicine Carcinoma Non-Small-Cell Lung Cause of Death Carcinoma medicine Humans Life Tables Prospective Studies Stage (cooking) Lung cancer Prospective cohort study Survival analysis Aged Neoplasm Staging Aged 80 and over business.industry Proportional hazards model Smoking Middle Aged medicine.disease Prognosis Survival Analysis United States Surgery Treatment Outcome Cohort Carcinoma Squamous Cell Female Cardiology and Cardiovascular Medicine business Cohort study Follow-Up Studies |
| Zdroj: | The Annals of thoracic surgery. 78(1) |
| ISSN: | 1552-6259 |
| Popis: | Gender has been reported as a predictor for nonsmall cell lung cancer (NSCLC) survival. Most of the reports are limited to selected groups of patients. The magnitude of gender effect on NSCLC survival across disease stage, tumor histology, and therapies needs to be further characterized.A cohort of 4,618 patients diagnosed with NSCLC was prospectively enrolled and actively followed. Vital status of each patient was verified through multiple complementary sources. Cox proportional hazards models were developed to compare postdiagnosis survival between genders adjusting for age at diagnosis, tumor histology and grade, stage, pack-years smoked, and treatment received (resection, radiation, or chemotherapy).There were 2,724 men (59%) and 1,894 women (41%), with a median age at diagnosis of 68 years in men and 66 in women (p0.01). More men smoked and were heavier smokers than women. Adenocarcinoma was the most frequent histology in both genders. No difference was found in stage and treatment between genders. The estimated survival in men was 51% (95% CI: 49%, 53%) and 15% (95% CI: 12%, 17%) at one and five years, respectively, and in women was 60% (95% CI: 58%, 62%) and 19% (95% CI: 16%, 22%). Men were at a significantly increased risk of mortality compared to women following a diagnosis of NSCLC (adjusted relative risk: 1.20, 95% CI: 1.11, 1.30), particularly for patients with stage III/IV disease or adenocarcinoma.Male gender is confirmed to be an independent unfavorable prognostic indicator for NSCLC survival. |
| Databáze: | OpenAIRE |
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