Palivizumab: Four seasons in Russia
| Autor: | Kuznetsova Sn, Amirova Vr, Briukhanova Oa, Kovalev Ia, Leyla Namazova-Baranova, Zakharova Ni, Zernova LIu, Krivoshchekov Ev, Nesterenko Év, Safarov Aa, Davydova, Dmitry O. Ivanov, Potapova Mv, Keshishian Es, Rychkova Lv, Safina Ai, Filatova Na, Ianulevich Os, Ovsiannikov DIu, Galustian An, Korsunskiĭ Aa, Koltunov Ie, Vinogradova, Beliaeva Ia, Soldatova Ig, Gorev Vv, E. P. Zimina, Bokeria El, Krsheminskaia, Degtiareva Ea, Shakirova Rm, Alexander Baranov, Vlasova Ev, Gafarova Gv, Liubimenko Va, Turti Tv, Antoniuk, Zuev Vv, Skachkova Ma, Degtiarev Dn, Dolgikh Vv, Donits Im, Pavlova Ti, Nikolaev Sv, Aliamovskaia Ga, Asmolova Ga |
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| Předmět: |
Palivizumab
Heart Defects Congenital Male Pediatrics medicine.medical_specialty Disease Respiratory Syncytial Virus Infections Antibodies Monoclonal Humanized Medical care Antiviral Agents Russia Risk groups Risk Factors Epidemiology Medicine Humans Infant Very Low Birth Weight Clinical efficacy Registries Bronchopulmonary Dysplasia business.industry Immunization Programs Infant Newborn virus diseases Infant General Medicine medicine.disease Immunization Bronchopulmonary dysplasia Female business Infant Premature medicine.drug Program Evaluation |
| Zdroj: | Scopus-Elsevier |
| Popis: | In 2010, the Russian Federation (RF) registered palivizumab--innovative drug, based on monoclonal antibodies for passive immunization of seasonal respiratory syncytial virus (RSV) infection in children of disease severe progress risk group, which include primarily premature infants, children with bronchopulmonary dysplasia and hemodynamically significant congenital heart disease. Currently, palivizumab is included in the list of recommended medicines and medical care standards of different countries, including Russia. In the review the results of Russian research on the progress of RSV infection, its epidemiology and immunization experience gained over the 2010-2014 period are summarized in relation to the foreign data. During the four epidemic seasons palivizumab immunization covered more than 3,200 children of severe RSV infection risk group with a progressive annual increase in the number of patients who received the drug. Geography of palivizumab immunization is also greatly expanded in our country during this time. If during the first two seasons measures of immunization were taken mainly in Moscow and St. Petersburg, at the present time, thirty one territorial entities of the Russian Federation have the experience in the drug application. Analysis of the results of RSV infection immunization (made in several regions) confirms the high clinical efficacy and palivizumab safety already demonstrated in international studies. In addition, the analysis presents the potential to improve the efficiency of the integrated RSV infection immunization programs, realizing in the establishment of high-risk child group register, adequate counseling for parents, as well as the development of the routing of patients and coordination of interaction between different health institutions during the immunization. |
| Databáze: | OpenAIRE |
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