Metabolic and ultrastructural characteristics of biosynthetic processes in the cerebral cortex at 3 months following a prolonged hemorrhagic shock
| Autor: | Novoderzhkina Is, Zh. V. Solov'eva, Smirnova Nv, Kozhura Vl |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Resuscitation Acid Phosphatase Cell Shock Hemorrhagic Emergency Nursing Adenosine Triphosphate Dogs Organelle Animals Medicine Brain Chemistry Cerebral Cortex Neurons business.industry Biological membrane DNA Alkaline Phosphatase Microscopy Electron Oligodendroglia medicine.anatomical_structure Cerebral cortex Astrocytes Shock (circulatory) Emergency Medicine Ultrastructure RNA Alkaline phosphatase medicine.symptom Cardiology and Cardiovascular Medicine business Intracellular |
| Zdroj: | Resuscitation. 21:89-102 |
| ISSN: | 0300-9572 |
| Popis: | Biochemical indicators (the content of ATP, total RNA and DNA, acid and alkaline phosphatase activity) and ultrastructural changes in cells of the nerve tissue were studied in the cerebral cortex of anesthetized dogs 3 months after they had sustained a 4-h hemorrhagic shock (arterial pressure = 40 mmHg). A new variant of reconstruction of cell membranes and organelles that develops in neurons and gliocytes of the brain in the process of adaptation 3 months after resuscitation is identified. This reconstruction variant is described by (a) the presence of a monolayer of a substance with a medium electron density with the incorporated dense granules instead of the common three-layer organisation; (b) the ability displayed by the organellar structure to detect "errors" in its organisation; (c) changes in the character of intercellular relations. The development of this variant of cell structure in the postresuscitation period is likely to be based on the information disintegration of a cell as a system, resulting in distortion of biosynthesis of supracellular ensembles and biological membranes of nerve cells in particular. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|