Second-trimester uterine evacuation: A comparison of intra-amniotic (15S)-15-methyl-prostaglandin F2α and intravaginal misoprostol
| Autor: | William E. Roberts, Rick W. Martin, Brian K. Rinehart, Kenneth G. Perry, Warren L. May, Dom A. Terrone |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors medicine.medical_treatment Blood Loss Surgical Uterus Prostaglandin Gestational Age Injections chemistry.chemical_compound Pregnancy medicine Humans Amnion Adverse effect Misoprostol Gynecology Abortifacient Agents Nonsteroidal Fetus Chemotherapy Carboprost Dose-Response Relationship Drug business.industry Abortifacient Agents Steroidal Obstetrics and Gynecology Therapeutic abortion Administration Intravaginal Treatment Outcome medicine.anatomical_structure Vacuum Curettage chemistry Pregnancy Trimester Second Female Intravaginal administration business Abortion Eugenic medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 181:1057-1061 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(99)70081-5 |
| Popis: | Objective: Our purpose was to compare the efficacy, safety, and adverse effects of intra-amniotically administered (15S)-15-methyl-prostaglandin F 2α and intravaginally administered misoprostol for second-trimester uterine evacuation. Study Design: Fifty-one patients were randomly assigned to receive either a single 2.5-mg intra-amniotic injection of (15S)-15-methyl-prostaglandin F 2 α (n = 26) or two 200-μg intravaginal doses of misoprostol (n = 25) at 12-hour intervals. The primary outcome measured was evacuation of the uterus within 24 hours. Results: The mean time from initiation of termination to uterine evacuation was less in the prostaglandin group than in the misoprostol group (17.5 ± 8.6 hours vs 22.3 ± 12.5 hours), but this was not statistically significant ( P > .05). The rate of successful fetal evacuation at 24 hours was significantly higher in the prostaglandin group than in the misoprostol group (88% vs 60%, P = .02). The complete-abortion rate and the incidence of adverse effects were similar in both groups. Conclusion: The use of an intra-amniotic injection of (15S)-15-methyl-prostaglandin F 2α for midtrimester pregnancy termination is safe and is associated with a greater number of successful uterine evacuations within 24 hours, without an increase in adverse effects, than intravaginal administration of misoprostol. (Am J Obstet Gynecol 1999;181:1057-61.) |
| Databáze: | OpenAIRE |
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