Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging : The ULSAM Cohort Revisited
| Autor: | Eric Rullman, Max Grönholdt-Klein, Anu Hedman, Thomas Gustafsson, Brun Ulfhake, Anna Strömberg, Elisabeth Skoglund, Lars-Eric Thornell, Tommy Cederholm |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gerontology Male medicine.medical_specialty Longitudinal study Aging Sarcopenia Population Muscle Fibers Skeletal Geriatrik Muscle Proteins Skeletal muscle Cohort Studies 03 medical and health sciences 0302 clinical medicine E3 ligases Medicine Humans Longitudinal Studies Muscle Strength RNA Messenger Healthy aging education Muscle Skeletal Aged Geriatrics Aged 80 and over Sweden education.field_of_study Successful aging business.industry Longitudinal muscle Middle Aged medicine.disease 030104 developmental biology Cohort Body Composition Independent Living Gene expression Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Popis: | Participants of the population-based Uppsala longitudinal study of adult men (ULSAM) cohort reaching more than 88 years of age (survivors, S) were investigated at age 70, 82, and 88-90 and compared at 70 years with non-survivors (NS) not reaching 82 years. Body composition, muscle mass and muscle histology were remarkably stable over 18 years of advanced aging in S. Analysis of genes involved in muscle remodeling showed that S had higher mRNA levels of myogenic differentiation factors (Myogenin, MyoD), embryonic myosin (eMyHC), enzymes involved in regulated breakdown of myofibrillar proteins (Smad2, Trim32, MuRF1,) and NCAM compared with healthy adult men (n = 8). S also had higher mRNA levels of eMyHC, Smad 2, MuRF1 compared with NS. At 88 years, S expressed decreased levels of Myogenin, MyoD, eMyHC, NCAM and Smad2 towards those seen in NS at 70 years. The gene expression pattern of S at 70 years was likely beneficial since they maintained muscle fiber histology and appendicular lean body mass until advanced age. The expression pattern at 88 years may indicate a diminished muscle remodeling coherent with a decline of reinnervation capacity and/or plasticity at advanced age. Elisabeth Skoglund, Max Grönholdt-Klein and Eric Rullman are joint first authors. Brun Ulfhake and Thomas Gustafsson are joint last authors. |
| Databáze: | OpenAIRE |
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