The Cognitive Effects of Statins are Modified by Age

Autor: Helgi B. Schiöth, Gaia Olivo, Laura Emily Clemensson, Ahmed Mohammed Alsehli, Michael Williams
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Gerontology
Male
Statin
medicine.drug_class
Population
Hypercholesterolemia
lcsh:Medicine
030204 cardiovascular system & hematology
Neuropsychological Tests
Article
Learning and memory
03 medical and health sciences
Population screening
0302 clinical medicine
Cognition
Reaction Time
Medicine
Humans
Gerontologi
medicinsk/hälsovetenskaplig inriktning
Effects of sleep deprivation on cognitive performance
Gerontology
specialising in Medical and Health Sciences
education
lcsh:Science
Drug safety
Problem Solving
Aged
education.field_of_study
Multidisciplinary
Working memory
business.industry
lcsh:R
Case-control study
Age Factors
Cognitive neuroscience
Middle Aged
Biobank
United Kingdom
Memory
Short-Term
Neurology
Case-Control Studies
Observational study
lcsh:Q
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Cognition Disorders
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
ISSN: 2045-2322
Popis: To reveal new insights into statin cognitive effects, we performed an observational study on a population-based sample of 245,731 control and 55,114 statin-taking individuals from the UK Biobank. Cognitive performance in terms of reaction time, working memory and fluid intelligence was analysed at baseline and two follow-ups (within 5–10 years). Subjects were classified depending on age (up to 65 and over 65 years) and treatment duration (1–4 years, 5–10 years and over 10 years). Data were adjusted for health- and cognition-related covariates. Subjects generally improved in test performance with repeated assessment and middle-aged persons performed better than older persons. The effect of statin use differed considerably between the two age groups, with a beneficial effect on reaction time in older persons and fluid intelligence in both age groups, and a negative effect on working memory in younger subjects. Our analysis suggests a modulatory impact of age on the cognitive side effects of statins, revealing a possible reason for profoundly inconsistent findings on statin-related cognitive effects in the literature. The study highlights the importance of characterising modifiers of statin effects to improve knowledge and shape guidelines for clinicians when prescribing statins and evaluating their side effects in patients.
Databáze: OpenAIRE
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