Kounis syndrome is likely culprit of coronary vasospasm induced by capecitabine
| Autor: | Grigorios Tsigkas, George Almpanis, Andreas Mazarakis, Nicholas G. Kounis |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Antimetabolites Antineoplastic Allergy medicine.medical_specialty Coronary Vasospasm Kounis syndrome Deoxycytidine Capecitabine medicine Humans Pharmacology (medical) Cardiotoxicity business.industry Pyogenic granuloma medicine.disease Dermatology Rash Oncology Coronary vasospasm Anesthesia Ventricular Fibrillation Ventricular fibrillation Fluorouracil medicine.symptom business medicine.drug |
| Zdroj: | Journal of Oncology Pharmacy Practice. 18:316-318 |
| ISSN: | 1477-092X 1078-1552 |
| DOI: | 10.1177/1078155211423118 |
| Popis: | Capecitabine administration has been associated with various allergic reactions including acneiform skin rash, linchenoid photosensitive eruption, exudative non healing scalp, skin reactions, pyogenic granuloma, subacute cutaneous systemic lupus erythematosus, exudative hyponychia dermatitis, and hand–foot syndrome. A patient who developed ventricular fibrillation following capecitabine-induced coronary vasospasm and necessitating cardioverter-defibrillator implantation was published recently in J Oncol Pharm Practice. The authors attributed this reaction to capecitabine cardiotoxicity, but capecitabine hypersensitivity is closely associated with Kounis syndrome. Tests and measures which will help to confirm, prevent and treat cardiac hypersensitivity to antineoplastic agents are recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|