Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
| Autor: | Tore K Kvien, Karl A. Brokstad, Hilde Berner Hammer, Hilde Haugedal Nordal, Magne Solheim, Anne-Kristine Halse |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Interleukin 6 Enzyme-Linked Immunosorbent Assay Gastroenterology S100A8 Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Synovitis Internal medicine Ultrasound medicine Humans Longitudinal Studies Rheumatoid arthritis 030203 arthritis & rheumatology Calprotectin medicine.diagnostic_test business.industry Middle Aged medicine.disease Rheumatology 030104 developmental biology S100A12 Erythrocyte sedimentation rate Antirheumatic Agents Immunology Biomarker (medicine) Female Vascular endothelial growth factor business Leukocyte L1 Antigen Complex Rheumatism Biomarkers Research Article |
| Zdroj: | Arthritis Research & Therapy |
| ISSN: | 1478-6362 1478-6354 |
| Popis: | Background Calprotectin (S100A8/A9 or MRP8/14) and S100A12 (leukocyte-derived proteins), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) are markers of inflammation and angiogenesis. Ultrasound (US) is sensitive for detection of greyscale synovitis and power Doppler (PD) vascularization. The objective of the present study was to explore the associations between calprotectin, S100A12, IL-6, VEGF, erythrocyte sedimentation rate, C-reactive protein and a comprehensive US assessment in patients with rheumatoid arthritis (RA) starting biologic disease-modifying anti-rheumatic drug (bDMARD) treatment. Methods A total of 141 patients with RA were assessed by US, clinical examination and biomarker levels at baseline and at 1, 2, 3, 6 and 12 months after initiation of bDMARDs. US assessment of 36 joints and 4 tendon sheaths were scored semi-quantitatively (0–3 scale). European League Against Rheumatism (EULAR) response was calculated. Statistical assessments performed to explore the associations between biomarkers and US sum scores included Spearman’s rank correlation analysis as well as linear and linear mixed model regression analyses. Results Calprotectin showed the overall strongest correlations with both US sum scores (r s = 0.25–0.62) and swollen joint counts (of 32) (r s = 0.24–0.47) (p |
| Databáze: | OpenAIRE |
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