High risk of bacterobilia in advanced experimental chronic fasciolosis
| Autor: | M. A. Valero, Miriam Navarro, Antonio Marcilla, José L. Hernández, Maria Morales, Santiago Mas-Coma, M. A. Garcia-Bodelon, P. Mengual |
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| Rok vydání: | 2006 |
| Předmět: |
Fascioliasis
medicine.medical_specialty Klebsiella pneumoniae Biliary Tract Diseases Veterinary (miscellaneous) Helminthiasis Biology Gastroenterology Enterococcus faecalis Sepsis Internal medicine Escherichia coli medicine Animals Bile Humans Fasciola hepatica Fasciolosis Rats Wistar Biliary Tract Bacterial Infections medicine.disease biology.organism_classification Culture Media Rats Disease Models Animal Infectious Diseases Liver Insect Science Chronic Disease Immunology Alkaline phosphatase Parasitology Bacteria |
| Zdroj: | Acta Tropica. 100:17-23 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/j.actatropica.2006.09.002 |
| Popis: | Fasciolosis is recognized as an important human disease. Wistar rats experimentally infected with Fasciola hepatica were examined using data obtained in the advanced chronic state of the disease (200, 300 and 400 days post-infection, dpi). Pigment stones (PS) and bile specimens were collected. The same procedure was applied in control rats. Liver tests were determined using stored serum samples. Bacteriological bile culture revealed viable bacteria (Escherichia coli, 45% of cases, Enterococcus faecalis, 45% and Klebsiella pneumoniae, 10%). The presence of bacterobilia was associated with liver serum enzymes, including aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT or SGPT), alkaline phosphatase (AP) and total bilirubin levels. Multivariate analysis suggested an association between bacterobilia and the following factors: duration of parasitic infection and intensity of parasitic infection supported the impression that the obstruction caused by advanced chronic fasciolosis in the rat may be related to biliary sepsis. Extrapolation to human infection in fasciolosis hyperendemic areas is discussed. In conclusion, the results of the rodent model should lead to a reconsideration of treatment features in human disease, i.e. therapeutic strategies should not only include a parasitic treatment but also consider the possibility of bacterial co-infection. |
| Databáze: | OpenAIRE |
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