Immunometabolism in the pathogenesis of systemic lupus erythematosus: an update
| Autor: | Jorge Romo-Tena, Mariana J. Kaplan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Neutrophils Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology immune system diseases medicine Humans Lupus Erythematosus Systemic Epigenetics skin and connective tissue diseases 030203 arthritis & rheumatology Innate immune system Systemic lupus erythematosus business.industry Macrophages Translational medicine Lipid metabolism medicine.disease Oxidative Stress 030104 developmental biology Immunology business Reprogramming |
| Zdroj: | Current opinion in rheumatology. 32(6) |
| ISSN: | 1531-6963 |
| Popis: | Purpose of review To provide an update on state-of-the-art evidence on the role of immunometabolism reprogramming in the pathogenesis of systemic lupus erythematosus (SLE). Recent findings Mitochondrial dysfunction and enhanced oxidative stress, along with specific defects in other metabolic pathways, can promote dysregulation of innate and adaptive immune responses in SLE. These abnormalities appear to be driven by genetic and epigenetic factors, modulated by stochastic events. In addition to extensive descriptions of abnormalities in immunometabolism of lupus lymphocytes, recent studies support the critical role of dysregulation of metabolic pathways in innate immune cells including neutrophils, macrophages and dendritic cells, in SLE pathogenesis. Recent abnormalities described in lipid metabolism have been associated with SLE disease activity and related damage. Promising therapeutic strategies that target these metabolic abnormalities have recently been described in SLE. Summary Fundamental new insights regarding the role of mitochondrial dysfunction in innate immune dysregulation in SLE pathogenesis have recently emerged. Defects in specific molecular pathways pertinent to immunometabolism in SLE have been described. New insights in translational medicine and promising therapeutic targets have been proposed based on these recent findings. |
| Databáze: | OpenAIRE |
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