Condyle modeling stability, craniofacial asymmetry and ACTN3 genotypes: Contribution to TMD prevalence in a cohort of dentofacial deformities

Autor: Joël Ferri, Romain Nicot, Kay Chung, Gwénaël Raoul, Alexandre R. Vieira, James J. Sciote
Přispěvatelé: Bodescot, Myriam, Department of Oral and Maxillofacial Surgery [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Pittsburgh (PITT), This work is supported by the National Institute of Dental & Craniofacial research through a grant to Dr. Sciote, Musculoskeletal Heritable Influences on Malocclusion - R21DE022427., Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
Single Nucleotide Polymorphisms
Orthognathic surgery
[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Orthognathic Surgical Procedures
0302 clinical medicine
Skeletal Joints
Medicine and Health Sciences
Actinin
Pyrophosphatases
Musculoskeletal System
Orthodontics
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Multidisciplinary
Dentofacial Deformities
Temporomandibular Joint Disorders
Chin
Models
Dental
3. Good health
Masticatory force
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Physical Sciences
Medicine
Female
Anatomy
Research Article
Adult
Science
Geometry
Pain
Surgical and Invasive Medical Procedures
Polymorphism
Single Nucleotide
Condyle
03 medical and health sciences
Signs and Symptoms
stomatognathic system
medicine
Genetics
Humans
Genetic Predisposition to Disease
Skeleton
Genetic Association Studies
business.industry
Phosphoric Diester Hydrolases
Mandibular Condyle
Asymmetry
Biology and Life Sciences
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
030206 dentistry
Myalgia
medicine.disease
Temporomandibular joint
stomatognathic diseases
030104 developmental biology
Jaw
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Face
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Craniofacial asymmetry
Malocclusion
Clinical Medicine
business
Head
Mathematics
Zdroj: PLoS ONE
PLoS ONE, 2020, 15 (7), pp.e0236425. ⟨10.1371/journal.pone.0236425⟩
PLoS ONE, Public Library of Science, 2020, 15 (7), pp.e0236425. ⟨10.1371/journal.pone.0236425⟩
PLoS ONE, Vol 15, Iss 7, p e0236425 (2020)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0236425⟩
Popis: International audience; Craniofacial asymmetry, mandibular condylar modeling and temporomandibular joint disorders are common comorbidities of skeletally disproportionate malocclusions, but etiology of occurrence together is poorly understood. We compared asymmetry, condyle modeling stability and temporomandibular health in a cohort of 128 patients having orthodontics and orthognathic surgery to correct dentofacial deformity malocclusions. We also compared ACTN3 and ENPP1 genotypes for association to clinical conditions. Pre-surgical posterior-anterior cephalometric and panometric radiographic analyses; jaw pain and function questionnaire and clinical examination of TMD; and SNP-genotype analysis from saliva samples were compared to assess interrelationships. Almost half had asymmetries in need of surgical correction, which could be subdivided into four distinct morphological patterns. Asymmetric condyle modeling between sides was significantly greater in craniofacial asymmetry, but most commonly had an unanticipated pattern. Often, longer or larger condyles occurred on the shorter mandibular ramus side. Subjects with longer ramus but dimensionally smaller condyles were more likely to have self-reported TMD symptoms (p = 0.023) and significantly greater clinical diagnosis of TMD (p = 0 .000001), with masticatory myalgia most prominent. Genotyping found two significant genotype associations for ACTN3 rs1671064 (Q523R missense) p = 0.02; rs678397 (intronic SNP) p = 0.04 and one significant allele association rs1815739 (R577X nonsense) p = 0.00. Skeletal asymmetry, unusual condyle modeling and TMD are common and interrelated components of many dentofacial deformities. Imbalanced musculoskeletal functional adaptations and genetic or epigenetic influences contribute to the etiology, and require further investigation.
Databáze: OpenAIRE
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