Evaluation of the effect of an ayurvedic formulation Myostaal Forte tablets on chondroprotective biomarkers in an experimental model of osteoarthritis in rats
| Autor: | Vetrivel Babu Nagarajan, Shetty Yc, Chawda M, Rege Nn, Singh Vk, Manjesh Ps, Patil P |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cartilage oligomeric matrix protein
medicine.medical_specialty biology Experimental model business.industry Bone markers COMP Osteoarthritis medicine.disease Chondrocyte Symptomatic relief Gastroenterology Chondroprotection Monosodium iodoacetate Other systems of medicine Internal medicine MMP-13 medicine biology.protein Histopathology business Progressive disease RZ201-999 |
| Zdroj: | Phytomedicine Plus, Vol 1, Iss 3, Pp 100082-(2021) |
| ISSN: | 2667-0313 |
| Popis: | Background: Osteoarthritis is a chronic progressive disease commonly affecting the hip and knee joints. Although many drugs are available and afford symptomatic relief, their side effects pose limitations to their continuous use. Introduction: Myostaal Forte (MF) is a poly-herbal Ayurvedic formulation that has shown protection against damage to the chondrocyte layer on histopathological examination in previous studies. But biomarkers which are indicative of chondroprotection have not been assessed. So, the present study was planned to reconfirm the protective effect of MF in osteoarthritic rats by histopathology and create a more substantial evidence by assessing the levels of Cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-13 (MMP-13). Methods: 32 rats were divided into four groups (n = 8 each group); sham control (SC), disease control (DC), positive control (PC) and a MF group. Behavioural tests were compared from baseline to 7th day, 14th day, 21st day and on 28th day. Histopathology and bone markers were compared on the 28th day. p |
| Databáze: | OpenAIRE |
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