Clinical sciences and orthopaedics: case report homozygous APC resistance in an elite athlete
| Autor: | Thomas Hilberg, M. Hartard, D. Jeschke, C. Moessmer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Physical Therapy Sports Therapy and Rehabilitation Thrombophilia Internal medicine Factor V Leiden Medicine Humans Point Mutation Orthopedics and Sports Medicine Risk factor Activated Protein C Resistance biology business.industry Vascular disease Homozygote Factor V Heparin medicine.disease Thrombosis Surgery biology.protein Female Blood Coagulation Tests business Protein C medicine.drug Sports |
| Zdroj: | International journal of sports medicine. 20(3) |
| ISSN: | 0172-4622 |
| Popis: | We report the case of a 31 year old female elite athlete. During a routine check-up including a search for hereditary hemostatic risk factors for thrombosis, resistance to activated protein C was detected. Molecular analysis of the factor V gene revealed homozygosity for the factor V Leiden mutation. This is the first documented case of an elite athlete who is a homozygous carrier of factor V Leiden. Elite athletes may be exposed to several circumstantial thrombogenic risk factors and, therefore, special preventive measures in carriers of a congenital risk factor such as APC resistance are indicated. Essential measures are early anticoagulation during periods of immobilisation e.g. after sports-related injuries, a single dose of low-molecular-weight heparin specially for individuals with several thrombotic risk factors and/or leg muscle exercises for long-distance (air) travels and avoiding haemoconcentration with a sufficient oral fluid intake. |
| Databáze: | OpenAIRE |
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