Effects of Psychotherapy on DNA Strand Break Accumulation Originating from Traumatic Stress
| Autor: | Maria Moreno-Villanueva, Maggie Schauer, Iris-Tatjana Kolassa, Thomas Elbert, Gilava Hamuni, Stephan Kolassa, Martina Ruf-Leuschner, Alexander Bürkle, Julia Morath |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Psychotherapist Adolescent DNA Repair DNA damage DNA repair medicine.medical_treatment Stress disorders Post-traumatic Complications Exposure therapy Implosive Therapy Posttraumatisches Stresssyndrom medicine.disease_cause DNA Strand Break DNS-Strangbruch Stress Disorders Post-Traumatic Young Adult chemistry.chemical_compound Narrative Exposure Therapy ddc:150 ddc:570 medicine Humans Adverse childhood experiences ddc:610 DNA breaks Narrative therapy Applied Psychology DDC 150 / Psychology DNA damage and repair DNA Breaks Traumatic stress Case-control study PTSD General Medicine Middle Aged Inflammatory cytokines Psychotherapie Psychiatry and Mental health Clinical Psychology chemistry Case-Control Studies Female Narrative Therapy Psychology Carcinogenesis DDC 610 / Medicine & health Stress Psychological DNA |
| Zdroj: | Psychotherapy and Psychosomatics. 83:289-297 |
| ISSN: | 1423-0348 0033-3190 |
| Popis: | Background: Previous research reveals an association between traumatic stress and an increased risk for numerous diseases, including cancer. At the molecular level, stress may increase carcinogenesis via increased DNA damage and impaired DNA repair mechanisms. We assessed DNA breakage in peripheral blood mononuclear cells from individuals with post-traumatic stress disorder (PTSD) and measured the cellular capacity to repair single-strand breaks after exposure to ionizing X-radiation. We also investigated the effect of psychotherapy on both DNA breakage and DNA repair. Methods: In a first study we investigated DNA breakage and repair in 34 individuals with PTSD and 31 controls. Controls were subdivided into 11 trauma-exposed subjects and 20 individuals without trauma exposure. In a second study, we analysed the effect of psychotherapy (Narrative Exposure Therapy) on DNA breakage and repair. Thirty-eight individuals with PTSD were randomly assigned to either a treatment or a waitlist control condition. Follow-up was performed 4 months and 1 year after therapy. Results: In study 1 we found higher levels of basal DNA breakage in individuals with PTSD and trauma-exposed subjects than in controls, indicating that traumatic stress is associated with DNA breakage. However, single-strand break repair was unimpaired in individuals with PTSD. In study 2, we found that psychotherapy reversed not only PTSD symptoms, but also DNA strand break accumulation. Conclusion: Our results show - for the first time in vivo - an association between traumatic stress and DNA breakage; they also demonstrate changes at the molecular level, i.e., the integrity of DNA, after psychotherapeutic interventions. publishedVersion |
| Databáze: | OpenAIRE |
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