Sampling of fluid through skin with magnetohydrodynamics for noninvasive glucose monitoring

Autor: Alejandro Garcia Perez, Emily Kemp, Tuuli A. Hakala, Melissa Wardale, Kim Pettersson-Fernholm, Ida A. Ruuth, Zhanna A. Boeva, Teemu A. Nurminen, Johan Bobacka, Edward Hæggström, Risto T. Vänskä, Juha Matti Alakoskela
Přispěvatelé: Department of Physics, Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, Department of Medicine, Helsinki University Hospital Area, Nefrologian yksikkö
Jazyk: angličtina
Rok vydání: 2021
Předmět:
EXTRACTION
Swine
Science
116 Chemical sciences
REVERSE IONTOPHORESIS
Wearable computer
02 engineering and technology
Biosensing Techniques
010402 general chemistry
01 natural sciences
Article
Techniques and instrumentation
PORCINE
Human health
Wearable Electronic Devices
Interstitial fluid
Skin Physiological Phenomena
SENSORS
Diabetes Mellitus
Medicine
Animals
Porcine skin
IN-VIVO
Skin
Multidisciplinary
Noninvasive sampling
Continuous glucose monitoring
business.industry
Blood Glucose Self-Monitoring
Sampling (statistics)
Extracellular Fluid
Bioanalytical chemistry
021001 nanoscience & nanotechnology
POTASSIUM
0104 chemical sciences
3. Good health
Glucose
3121 General medicine
internal medicine and other clinical medicine
Models
Animal
Hydrodynamics
Magnets
UREA
0210 nano-technology
business
Biomedical engineering
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
ISSN: 2045-2322
Popis: Out of 463 million people currently with diabetes, 232 million remain undiagnosed. Diabetes is a threat to human health, which could be mitigated via continuous self-monitoring of glucose. In addition to blood, interstitial fluid is considered to be a representative sample for glucose monitoring, which makes it highly attractive for wearable on-body sensing. However, new technologies are needed for efficient and noninvasive sampling of interstitial fluid through the skin. In this report, we introduce the use of Lorentz force and magnetohydrodynamics to noninvasively extract dermal interstitial fluid. Using porcine skin as an ex-vivo model, we demonstrate that the extraction rate of magnetohydrodynamics is superior to that of reverse iontophoresis. This work seeks to provide a safe, effective, and noninvasive sampling method to unlock the potential of wearable sensors in needle-free continuous glucose monitoring devices that can benefit people living with diabetes.
Databáze: OpenAIRE
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