Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
| Autor: | Sayed S. Daoud, Matthew M. Yeh, Dustin E Bosch |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cirrhosis
Colorectal cancer Hepatocellular carcinoma Gastrointestinal Diseases Review 03 medical and health sciences 0302 clinical medicine Gastrointestinal tract medicine Humans Protein Isoforms Viral hepatitis business.industry Liver Diseases Gastroenterology General Medicine medicine.disease 3. Good health Hepatocyte nuclear factors Colorectal carcinoma medicine.anatomical_structure Gene Expression Regulation Hepatocyte Nuclear Factor 4 Gastrointestinal disease Hepatocyte nuclear factor 4 alpha 030220 oncology & carcinogenesis Liver cirrhosis Cancer research Disease Progression 030211 gastroenterology & hepatology Liver function Transcription factor Pancreas business Hepatocyte nuclear factor 4-alpha |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 |
| Popis: | Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α expression has been associated with many human diseases such as ulcerative colitis, colon cancer, maturity-onset diabetes of the young, liver cirrhosis, and hepatocellular carcinoma. However, the precise role of HNF4α in the etiology of these human pathogenesis is not well understood. Limited information is known about the role of HNF4α isoforms in liver and gastrointestinal disease progression. There is, therefore, a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes. In this review, we will update our current understanding on the role of HNF4α in human liver and gastrointestinal diseases. We further provide additional information on possible use of HNF4α as a target for potential therapeutic approaches. |
| Databáze: | OpenAIRE |
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