Immunoreceptors on neutrophils
| Autor: | Hanke L. Matlung, Katka Szilagyi, Taco W. Kuijpers, Timo K. van den Berg, Dieke J van Rees |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Molecular cell biology and Immunology, AII - Cancer immunology, CCA - Cancer immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Syk spleen tyrosine kinase Neutrophils Syk GBS group B Streptococci MPO myeloperoxidase RA rheumatoid arthritis Plasma protein binding IVIg intravenous immunoglobulins GPI glycophosphatidylinositol Neutrophil Activation SLE systemic lupus erythematosus PTPN6 tyrosine-protein phosphatase non-receptor type 6 0302 clinical medicine SLP-76 SH2 domain containing leukocyte protein of 76 kDa ERK extracellular signal-regulated kinase PIP2 phosphatidylinositol (4 5)-bisphosphate ITAM SHP Immunology and Allergy Receptors Immunologic SHP SH2-domain containing phosphatase SOCS suppressor of cytokine signaling proteins Antibody-dependent cell-mediated cytotoxicity SHIP SH2-domain containing inositol phosphatase Effector DAP12 DNAX activation protein of 12 kDa hemic and immune systems PS phosphatidylserine ANCAs anti-neutrophil autoantibodies Cell biology IgSF Immunoglobulin superfamily Biochemistry PH domain pleckstrin homology domain PI(3 4)P2 phosphatidylinositol (3 4)-bisphosphate Disease Susceptibility Signal transduction SNP single-nucleotide polymorphism IP3 inositol triphosphate SHIP SH2 Src homology 2 PMN polymorphonuclear leukocytes Protein Binding Signal Transduction NETs neutrophil extracellular traps Immunology chemical and pharmacologic phenomena Biology Btk Bruton's tyrosine kinase PE phosphatidylethanolamine Article GEF guanine nucleotide exchange factor 03 medical and health sciences Immune system PLC phospholipase C ROS reactive oxygen species ORF open reading frame PKC protein kinase C Animals Humans ITAM immunoreceptor tyrosine-based activating motif MLCK myosin light-chain kinase Immunoreceptors PI3K/AKT/mTOR pathway GPCR G protein-coupled receptor G protein-coupled receptor DAG diacyl-glycerol ADCC antibody-dependent cellular cytotoxicity MRP8 myeloid-related protein 8 ITIM immunoreceptor tyrosine-based inhibitory motif NADPH nicotinamide adenine dinucleotide phosphate ITIM Immunity Innate IRAK interleukin-1 receptor-associated kinase Grb2 growth factor receptor-bound protein 2 030104 developmental biology Gene Expression Regulation PI3K phosphatidylinositol-4 5-bisphosphate 3-kinase fMLP N-Formylmethionine-leucyl-phenylalanine MAPK mitogen-activated protein kinase Biomarkers 030215 immunology PIP3 phosphatidylinositol (3 4 5)-trisphosphate |
| Zdroj: | van Rees, D J, Szilagyi, K, Kuijpers, T W, Matlung, H L & van den Berg, T K 2016, ' Immunoreceptors on neutrophils ', Seminars in immunology, vol. 28, no. 2, pp. 94-108 . https://doi.org/10.1016/j.smim.2016.02.004 Seminars in Immunology Seminars in immunology, 28(2), 94-108. Academic Press Inc. |
| ISSN: | 1044-5323 |
| DOI: | 10.1016/j.smim.2016.02.004 |
| Popis: | Highlights • Neutrophil activities must be tightly controlled to maintain immune homeostasis. • Activating and inhibitory receptors balance the outcome of immune cell activation. • Immunoreceptors contain Ig-like extracellular domains and signal via ITAMs or ITIMs. • Syk or SHP/SHIP mediate downstream signaling after immunoreceptor activation. • Targeting immunoreceptors provides opportunities for therapeutic interventions. Neutrophils play a critical role in the host defense against infection, and they are able to perform a variety of effector mechanisms for this purpose. However, there are also a number of pathological conditions, including autoimmunity and cancer, in which the activities of neutrophils can be harmful to the host. Thus the activities of neutrophils need to be tightly controlled. As in the case of other immune cells, many of the neutrophil effector functions are regulated by a series of immunoreceptors on the plasma membrane. Here, we review what is currently known about the functions of the various individual immunoreceptors and their signaling in neutrophils. While these immunoreceptors allow for the recognition of a diverse range of extracellular ligands, such as cell surface structures (like proteins, glycans and lipids) and extracellular matrix components, they commonly signal via conserved ITAM or ITIM motifs and their associated downstream pathways that depend on the phosphorylation of tyrosine residues in proteins and/or inositol lipids. This allows for a balanced homeostatic regulation of neutrophil effector functions. Given the number of available immunoreceptors and their fundamental importance for neutrophil behavior, it is perhaps not surprising that pathogens have evolved means to evade immune responses through some of these pathways. Inversely, some of these receptors evolved to specifically recognize these pathogens. Finally, some interactions mediated by immunoreceptors in neutrophils have been identified as promising targets for therapeutic intervention. |
| Databáze: | OpenAIRE |
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