Effects of ?3-adrenoceptor stimulation on prostaglandin E2-induced bladder hyperactivity and on the cardiovascular system in conscious rats
| Autor: | Kouichi Kaidoh, Yasuhiko Igawa, Hiroshi Miyata, Karl-Erik Andersson, Yoshinobu Yamazaki, Satoshi Akahane, Osamu Nishizawa, Hiroo Takeda, Masuo Akahane |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Atropine
Agonist medicine.medical_specialty medicine.drug_class Procaterol Urology media_common.quotation_subject Urinary Bladder Adrenergic beta-3 Receptor Agonists Blood Pressure Dioxoles Muscarinic Antagonists Urination Dinoprostone Rats Sprague-Dawley Heart Rate Internal medicine Catheterization Peripheral Heart rate Pressure medicine Animals Adrenergic beta-2 Receptor Agonists media_common Dose-Response Relationship Drug medicine.diagnostic_test business.industry Muscarinic antagonist Cystometry Adrenergic beta-Agonists medicine.disease Rats Endocrinology Overactive bladder Receptors Adrenergic beta-3 Female Receptors Adrenergic beta-2 Neurology (clinical) Urinary Catheterization business medicine.drug |
| Zdroj: | Neurourology and Urodynamics. 21:558-565 |
| ISSN: | 1520-6777 0733-2467 |
| Popis: | Aims. To investigate the effects of selective beta(2)- and selective beta(3)-adrenoceptor (AR) agonists on prostaglandin (PG) E-2-induced bladder hyperactivity in conscious free-moving rats. Methods. Female Sprague-Dawley rats were anesthetized for implantation of bladder, intravenous, and intra-arterial catheters. The effects of a beta(3)-AR agonist (CL316,243) on cystometric and cardiovascular parameters were assessed in conscious rats. Intravesical instillation of PGE(2) (20-60 muM, 6 mL/hr) in conscious rats produced a concentration-dependent increase in voiding frequency. Results. In this model i.v. CL316,243 (beta(3)-AR agonist) reduced basal bladder pressure, increased micturition volume, and prolonged micturition interval in a dose-dependent manner, without affecting threshold pressure or micturition pressure. On the other hand, i.v. procaterol (beta(2)-AR agonist) did not counteract the bladder hyperactivity. Atropine (muscarinic antagonist) reduced micturition pressure and micturition volume, and shortened micturition interval. CL316,243 slightly decreased mean blood pressure and increased heart rate only when given at high doses (10 and 100 mug/kg, iv.). In contrast, procaterol caused a significant decrease in mean blood pressure and a significant increase in heart rate. Atropine significantly increased heart rate. Conclusions. The present results clearly demonstrated that the beta(3)-AR agonist prolonged the micturition interval without producing significant cardiovascular side effects. The human detrusor, like the rat detrusor, relaxes on beta(3)-AR stimulation. Provided that these results are valid in humans, selective beta(3)-AR agonists might be clinically useful for controlling a certain type of bladder overactivity. (Less) |
| Databáze: | OpenAIRE |
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