Quantitative Validation of the Coronary Angioscopic Yellow Plaque with Lipid Core Burden Index Assessed by Intracoronary Near-Infrared Spectroscopy
| Autor: | Yasushi Sakata, Atsushi Hirayama, Yohei Sotomi, Tomoaki Kobayashi, Takashi Omatsu, Yoshiharu Higuchi, Yasunori Ueda, Yuma Hamanaka, Akio Hirata |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Coronary angioscopy medicine.medical_treatment Angioscopy Coronary Artery Disease 030204 cardiovascular system & hematology Positive correlation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal Medicine medicine Humans Prospective Studies Ultrasonography Interventional Aged Spectroscopy Near-Infrared medicine.diagnostic_test business.industry Biochemistry (medical) Ultrasound Percutaneous coronary intervention Coronary Vessels Lipids Vulnerable plaque Plaque Atherosclerotic Confidence interval Female Cardiology and Cardiovascular Medicine Lipid core business Nuclear medicine 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 29:362-369 |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | Aim We aimed to validate the subjective and qualitative angioscopic findings by the objective and quantitative near-infrared spectroscopic (NIRS) assessment to compensate each other's drawbacks. Methods This is a single-center prospective observational study. Patients undergoing a planned follow-up coronary angiography after percutaneous coronary intervention were prospectively enrolled from January 2018 to April 2019. The major three vessels were examined by NIRS-intravascular ultrasound, followed by coronary angioscopic evaluation. Yellow color grade on angioscopy was classified into four grades (0, white; 1, slight yellow; 2, yellow; and 3, intensive yellow) at a location of maximal lipid core burden index over 4 mm [LCBI (4)] on NIRS in each vessel. Results A total of 95 lesions in 44 patients (72.6±6.7 years, 75% male) were analyzed. LCBI (4) was significantly different among different yellow color grades by coronary angioscopy (ANOVA, p＜0.001). Positive correlation was found between angioscopic yellow color grade and LCBI (4) (beta coefficient 164.8, 95% confidence interval 122.9-206.7; p＜0.001). The best cutoff value of LCBI (4) to predict the presence of yellow plaque (yellow color grade ≥ 2) was 448 (sensitivity 79.3%, specificity 69.7%, C-statistic 0.800, 95% confidence interval 0.713-0.887, p＜0.001). Conclusion The qualitative angioscopic assessment was objectively validated by the quantitative NIRS evaluation, which would be helpful for the reinterpretation of the existing evidences of both imaging modalities. |
| Databáze: | OpenAIRE |
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