| Autor: |
Philip James Maltas, Edward A. Anderson, Jong Ho Lim, Stephen M. Dalby, Ian Paterson |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie. 124:2803-2807 |
| ISSN: |
0044-8249 |
| DOI: |
10.1002/ange.201108594 |
| Popis: |
Marine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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