Cognitive function, treatment response to lithium, and social functioning in Japanese patients with bipolar disorder

Autor:	Akiko Aoki, Kazuko Kato, Gyo Honda, Kazufumi Akiyama, Satoshi Saito, Haruhiko Asahi, Yuji Ozeki, Hayato Sato, Kazutaka Shimoda, Jinichi Kuroda, Kenichi Ohmori, Kumiko Fujii, Harunobu Mori
Rok vydání:	2017
Předmět:	Adult Male medicine.medical_specialty Bipolar Disorder Lithium (medication) Neuropsychological Tests Structural equation modeling 03 medical and health sciences Cognition 0302 clinical medicine Japan Antimanic Agents medicine Humans Cognitive Dysfunction Bipolar disorder Effects of sleep deprivation on cognitive performance Psychiatry Biological Psychiatry Intelligence quotient Middle Aged medicine.disease 030227 psychiatry Affect Psychiatry and Mental health Mood Schizophrenia Case-Control Studies Lithium Compounds Regression Analysis Female Psychology Social Adjustment 030217 neurology & neurosurgery Clinical psychology medicine.drug
Zdroj:	Bipolar Disorders. 19:552-562
ISSN:	1398-5647
Popis:	Objectives Patients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium-treated patients with bipolar disorder. Methods We evaluated 96 lithium-treated euthymic patients with bipolar disorder and 196 age- and-gender-matched healthy controls, using the Brief Assessment of Cognition in Schizophrenia (BACS). The patients were also assessed using the Social Functioning Scale (SFS) and “The Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” (Alda) scale, which was evaluated as either a continuous measure of the total scale or a dichotomous criterion. Results Multiple regression analysis revealed two key findings: first, that the premorbid intelligence quotient, age, and number of mood episodes were predictors of the BACS composite score; and, second, that the BACS composite score, negative symptoms, and continuous measure on the total Alda scale (but not its dichotomy) predicted the total SFS score. Structural equation modeling (SEM) was used to confirm these findings, and additionally revealed that the Alda scale was significantly associated with negative symptoms and also the number of mood episodes, regardless of how it was evaluated. Conclusions SEM delineated how demographic and clinical variables, cognitive performance, and response to lithium treatment were causally associated with, and converged on, social function. The putative role of the Alda scale for social function warrants further study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498b55d3617efe9071b04e631af6f0b0 https://doi.org/10.1111/bdi.12521 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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